TLE4 and CUX1

Number of citations of the paper that reports this interaction (PubMedID 19332113)
65

Data Source:
BioGRID (pull down)

		TLE4	CUX1
Description		TLE family member 4, transcriptional corepressor	cut like homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intra-Golgi Vesicle-mediated Transport Positive Regulation Of Dendrite Morphogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Bipolar disorder ( 34099189) Bipolar disorder x sex interaction ( 34099189) Chronotype ( 30696823) Daytime nap ( 33568662) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting insulin ( 34059833) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Motion sickness ( 25628336) Neutrophil percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Platelet count ( 32888494) Plateletcrit ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Type 2 diabetes ( 30718926 32499647 30297969 28869590 26818947 24509480 22885922)	Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 27539887 33549134 31174203) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: BRCA1 CRYAA CUX1 LIG4 MSX1 NUP62 OTX1 OTX2 PAX5 POU2F1 SRPK2	23 interacting genes: BIN1 CA12 CCNA1 CCNB1 CDC25A CDK1 CDK7 CHAF1B CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4
Entrez ID		7091	1523
HPRD ID		05502	00295
Ensembl ID		ENSG00000106829	ENSG00000257923
Uniprot IDs		A0A994J7T6 Q04727	P39880 Q13948 Q3LIA3
PDB IDs			8WQE 8WQF 8WQI
Enriched GO Terms of Interacting Partners?		Chromatin Midbrain Development DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Forebrain Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Embryonic Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Sensory Organ Development Regulation Of Metabolic Process Condensed Chromosome Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Centrosome Cycle Regulation Of Centrosome Duplication Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Centrosome Cycle Establishment Of Integrated Proviral Latency Negative Regulation Of Odontoblast Differentiation DNA-binding Transcription Factor Activity Diencephalon Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process P53 Binding	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle DNA-binding Transcription Factor Binding Nucleoplasm Mitotic Cell Cycle Phase Transition Cyclin B1-CDK1 Complex Cell Division Chromatin Remodeling Mitotic DNA-templated DNA Replication Cyclin A1-CDK1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Replication N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Chromosome Segregation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Sister Chromatid Segregation Positive Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Nuclear DNA Replication Regulation Of Chromosome Segregation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle DNA Repair Cell Cycle G2/M Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Ventricular Cardiac Muscle Cell Development
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