TLE4

Description		TLE family member 4, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Bipolar disorder ( 34099189) Bipolar disorder x sex interaction ( 34099189) Chronotype ( 30696823) Daytime nap ( 33568662) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting insulin ( 34059833) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Motion sickness ( 25628336) Neutrophil percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Platelet count ( 32888494) Plateletcrit ( 32888494) Severe insulin-resistant type 2 diabetes ( 34737425) Type 2 diabetes ( 30718926 32499647 30297969 28869590 26818947 24509480 22885922)
Interacting Genes		11 interacting genes: BRCA1 CRYAA CUX1 LIG4 MSX1 NUP62 OTX1 OTX2 PAX5 POU2F1 SRPK2
Entrez ID		7091
HPRD ID		05502
Ensembl ID		ENSG00000106829
Uniprot IDs		A0A994J7T6 Q04727
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Midbrain Development DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Forebrain Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Centriole Replication Embryonic Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Sensory Organ Development Regulation Of Metabolic Process Condensed Chromosome Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Centrosome Cycle Regulation Of Centrosome Duplication Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Centrosome Cycle Establishment Of Integrated Proviral Latency Negative Regulation Of Odontoblast Differentiation DNA-binding Transcription Factor Activity Diencephalon Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process P53 Binding
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