TLE4

Gene Name		transducin-like enhancer of split 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Molecular_function Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Biological_process Wnt Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 19714205)
Protein-protein Interactions		9 interactors: BRCA1 CUX1 LIG4 MSX1 OTX1 OTX2 PAX5 POU2F1 SRPK2
Entrez ID		7091
HPRD ID		05502
Ensembl ID		ENSG00000106829
Uniprot IDs		Q04727
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Embryo Development RNA Metabolic Process Sensory Organ Development Ear Development Positive Regulation Of Metabolic Process Diencephalon Morphogenesis Developmental Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Midbrain Development Diencephalon Development Positive Regulation Of Cellular Metabolic Process System Development Ear Morphogenesis Negative Regulation Of Histone Methylation Regulation Of RNA Metabolic Process Organ Morphogenesis Organ Development Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Forebrain Morphogenesis Cell Differentiation Gene Expression Inner Ear Development Nervous System Development Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Morphogenesis RNA Biosynthetic Process Anatomical Structure Morphogenesis
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