UTY and PRDX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UTY	PRDX2
Description		ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	peroxiredoxin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm MLL3/4 Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		HDMs demethylate histones	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Autism ( 32996047)	Platelet distribution width ( 32888494)
Interacting Genes		4 interacting genes: PRDX2 TLE1 TLE2 USP7	24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 CDK1 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PSEN1 RNF32 RPL4 SAT1 SUMO4 TXNDC5 UTY
Entrez ID		7404	7001
HPRD ID		02451	02763
Ensembl ID		ENSG00000183878	ENSG00000167815
Uniprot IDs		A0A087X0Y2 A0A087X248 A0A087X2I9 A0A096LPD8 A0A8C8KHL4 E1NZ93 E1U198 E1U1M3 E1U1M9 F4MH27 F4MH29 F4MH30 F4MH31 F4MH32 F4MH35 F4MH36 F4MH40 F4MH46 F4MH47 F4MH50 F4MH51 F4MH58 F4MH60 F4MH62 F4MH91 F4MH92 F5GWV3 F5H3N7 F5H8B4 O14607	P32119 V9HW12
PDB IDs		3ZLI 3ZPO 4UF0 5A1L 5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY7 5FYM	1QMV 5B8A 5B8B 5IJT 7KIZ 7KJ0 7KJ1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Regulation Of Signaling Thioredoxin Peroxidase Activity Transcription Regulator Complex Transcription Corepressor Activity Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Respiratory Burst Involved In Defense Response Regulation Of Wnt Signaling Pathway Monoubiquitinated Protein Deubiquitination Defense Response To Tumor Cell Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Production Of Molecular Mediator Involved In Inflammatory Response Beta-catenin-TCF Complex Nuclear Body DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Regulation Of Telomere Capping Removal Of Superoxide Radicals Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Hydrogen Peroxide Metabolic Process Signal Transduction Hydrogen Peroxide Catabolic Process Negative Regulation Of Anoikis Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity Respiratory Burst Antioxidant Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Blood Coagulation Animal Organ Morphogenesis Regulation Of Anoikis Deubiquitinase Activity Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Coagulation Peroxidase Activity	Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Lipoprotein Particle Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Meiotic Sister Chromatid Cohesion, Centromeric Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Rough Endoplasmic Reticulum Positive Regulation Of Protein Transport Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway Extracellular Exosome Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Signaling Response To Amyloid-beta Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Enzyme Binding Positive Regulation Of Proteolysis Low-density Lipoprotein Particle Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Signaling Pathway Protein Phosphatase Type 2A Complex Regulation Of Immune System Process Positive Regulation Of Signal Transduction Heparan Sulfate Proteoglycan Binding Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Localization To Nucleus High-density Lipoprotein Particle Dendrite Positive Regulation Of Glycolytic Process Amyloid Precursor Protein Metabolic Process
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