BARHL1 and TLE2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		BARHL1	TLE2
Gene Name		BarH-like homeobox 1	transducin-like enhancer of split 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Neuron Migration Transcription, DNA-templated Sensory Perception Of Sound Midbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: TLE1 TLE2	16 interactors: BARHL1 EMX2 FOXA3 H3F3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		56751	7089
HPRD ID		05554	03025
Ensembl ID		ENSG00000125492	ENSG00000065717
Uniprot IDs		Q9BZE3	B4DE62 K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Anoikis Regulation Of Anoikis Organ Morphogenesis Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Organ Development Regulation Of Signaling Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process System Development Organ Morphogenesis Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development RNA Biosynthetic Process Anterior/posterior Pattern Specification Cell Migration Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Cell Motility Mesenchymal Cell Development Cell Differentiation Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Gene Expression Central Nervous System Development Odontogenesis Mesenchymal Cell Differentiation Face Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of BMP Signaling Pathway Nucleobase-containing Compound Metabolic Process Activation Of Meiosis Generation Of Neurons Head Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
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