MMP3 and DCN

Number of citations of the paper that reports this interaction (PMID 9148753)
57

Data Source:
HPRD (in vitro)

		MMP3	DCN
Gene Name		matrix metallopeptidase 3 (stromelysin 1, progelatinase)	decorin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Mitochondrion Cytosol	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding
	Biological Process	Proteolysis Negative Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Negative Regulation Of Protein Kinase B Signaling Cellular Response To Amino Acid Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Oxidative Stress-induced Cell Death	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process
Pathways		Signaling by GPCR EGFR Transactivation by Gastrin Collagen formation Collagen degradation Gastrin-CREB signalling pathway via PKC and MAPK Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4\'-Methoxy-(1,1\'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4\'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
Diseases
GWAS		Alzheimer's disease ( 22832961)	Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		18 interactors: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11	30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1
Entrez ID		4314	1634
HPRD ID		01703	00501
Ensembl ID		ENSG00000149968	ENSG00000011465
Uniprot IDs		P08254	P07585 Q6FH10
PDB IDs		1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1M1W 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Cell Chemotaxis Leukocyte Migration Leukocyte Chemotaxis Cell Migration Granulocyte Chemotaxis Cell Motility Monocyte Chemotaxis Proteoglycan Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Locomotion Calcium Ion Homeostasis Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Proteolysis Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Processing Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Glycosaminoglycan Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Chondroitin Sulfate Metabolic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Peptidase Activity Inflammatory Response Regulation Of Cell-substrate Adhesion Developmental Process Negative Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Cell Motility Negative Regulation Of Cellular Protein Metabolic Process Metal Ion Homeostasis Regulation Of Catalytic Activity Platelet Degranulation Eosinophil Migration Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Negative Regulation Of Cellular Component Movement Response To External Stimulus Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Dermatan Sulfate Biosynthetic Process Negative Regulation Of Locomotion	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration
Tagcloud ?		6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley	architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion
Tagcloud (Difference) ?		6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley	architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion
Tagcloud (Intersection) ?