MTMR14 and EPHA7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		MTMR14	EPHA7
Description		myotubularin related protein 14	EPH receptor A7
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Growth Factor Binding Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Macroautophagy	Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Brain Development Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Negative Chemotaxis Neuron Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Regulation Of Postsynapse Organization
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Fostamatinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Adult body size ( 32376654) Adventurousness ( 30643258) Anthropometric traits (multi-trait analysis) ( 30166351) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Initial pursuit acceleration ( 29064472) Laryngeal squamous cell carcinoma ( 25194280) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to hepatitis C treatment ( 22095909) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		10 interacting genes: APP CFTR ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2 UBC	12 interacting genes: AFDN DUSP18 DUSP26 EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MTMR14 STYX ZNF267
Entrez ID		64419	2045
HPRD ID		08654	03721
Ensembl ID		ENSG00000163719	ENSG00000135333
Uniprot IDs		Q8NCE2 Q8WYY9	A0A7P0T9G1 A0A7P0T9L5 A0A7P0T9V9 A0A7P0TA58 Q15375
PDB IDs			2REI 3DKO 3H8M 3NRU 7EEC 7EED 7EEF
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Receptor Complex Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Axon Guidance Receptor Activity Neuron Projection Maintenance Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Long-term Synaptic Potentiation ATP Binding Retinal Ganglion Cell Axon Guidance Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Assembly Ephrin Receptor Binding Plasma Membrane Regulation Of Developmental Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Nucleotide Binding Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Hippocampal Mossy Fiber To CA3 Synapse Neuron Recognition Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Cellular Response To Amyloid-beta Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Axonogenesis Peptidyl-tyrosine Phosphorylation Branching Involved In Lymph Vessel Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Response To Amyloid-beta Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Guidance Axon Guidance Protein Serine/threonine Phosphatase Activity Transmembrane-ephrin Receptor Activity Protein Tyrosine/serine/threonine Phosphatase Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Pseudophosphatase Activity Phosphatase Activity Protein Dephosphorylation Regulation Of Cell Adhesion Notochord Formation F-box Domain Binding Protein Tyrosine Phosphatase Activity Plasma Membrane Bounded Cell Projection Organization Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Oxygen-glucose Deprivation
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