MTMR14 and EPHA1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		MTMR14	EPHA1
Description		myotubularin related protein 14	EPH receptor A1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Nucleotide Binding Fibronectin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Macroautophagy	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane	EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Family history of Alzheimer's disease ( 30617256) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		10 interacting genes: APP CFTR ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2 UBC	12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE
Entrez ID		64419	2041
HPRD ID		08654	01554
Ensembl ID		ENSG00000163719	ENSG00000146904
Uniprot IDs		Q8NCE2 Q8WYY9	P21709
PDB IDs			2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Receptor Complex Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Axon Guidance Receptor Activity Neuron Projection Maintenance Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Long-term Synaptic Potentiation ATP Binding Retinal Ganglion Cell Axon Guidance Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Assembly Ephrin Receptor Binding Plasma Membrane Regulation Of Developmental Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Nucleotide Binding Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Hippocampal Mossy Fiber To CA3 Synapse Neuron Recognition Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Cellular Response To Amyloid-beta Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Axonogenesis Peptidyl-tyrosine Phosphorylation Branching Involved In Lymph Vessel Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Response To Amyloid-beta Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Protein Modification Process Phosphoprotein Phosphatase Activity Phosphate-containing Compound Metabolic Process Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Cell Surface Receptor Signaling Pathway Protein Metabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Ephrin Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Engulfment Of Target By Autophagosome SMAD Binding Non-canonical Wnt Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Negative Regulation Of T Cell Proliferation ERBB3:ERBB2 Complex ERBB Signaling Pathway Cellular Response To Mechanical Stimulus Intestinal Epithelial Cell Migration Phosphatase Activity Protein Phosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phosphorylation Notochord Formation RNA Polymerase I Core Binding Cerebellar Cortex Formation Negative Regulation Of Leukocyte Proliferation Signal Transduction Regulation Of NMDA Receptor Activity Positive Regulation Of MAPK Cascade Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Immature T Cell Proliferation In Thymus Glial Cell Differentiation ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?