DBI and CYSLTR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		DBI	CYSLTR2
Description		diazepam binding inhibitor, acyl-CoA binding protein	cysteinyl leukotriene receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Protein-lipid Complex Extracellular Exosome Perinuclear Endoplasmic Reticulum	Plasma Membrane Membrane
	Molecular Function	Fatty-acyl-CoA Binding Protein Binding Lipid Binding Benzodiazepine Receptor Binding Long-chain Fatty Acyl-CoA Binding Identical Protein Binding	Cysteinyl Leukotriene Receptor Activity G Protein-coupled Receptor Activity Galanin Receptor Activity Leukotriene Receptor Activity Protein Binding
	Biological Process	Fatty Acid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Negative Regulation Of Protein Lipidation Positive Regulation Of Phospholipid Transport	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways		Mitochondrial Fatty Acid Beta-Oxidation	Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events LTC4-CYSLTR mediated IL4 production
Drugs		Coenzyme A Hexadecanal	Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS		Obesity-related traits ( 23251661)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		14 interacting genes: CYSLTR2 DDIT4L DUSP23 GSK3B LAMTOR5 MAP1LC3B NIPSNAP1 NSFL1C PFDN2 PPCDC RAD23A RAD23B TSPO UBXN2A	19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE
Entrez ID		1622	57105
HPRD ID		08832	09293
Ensembl ID		ENSG00000155368	ENSG00000152207
Uniprot IDs		A0A024RAF2 B8ZWD1 B8ZWD8 P07108	A4ZKH2 Q5KU17 Q9NS75
PDB IDs		2CB8 2FJ9
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Centrosome Proteasomal Protein Catabolic Process Autophagosome Assembly Autophagosome Organization Protein Catabolic Process Proteasome Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Organelle Assembly Nuclear Membrane Reassembly Regulation Of Proteolysis Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Catabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Corticosterone Secretion Regulation Of Protein Metabolic Process Regulation Of Microtubule Anchoring At Centrosome Nuclear Membrane Organization Cysteinyl Leukotriene Receptor Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex Nucleotide-excision Repair Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Mitophagy Membrane Assembly Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Proteasome Complex Damaged DNA Binding Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Autophagy Of Mitochondrion VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway
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