CCDC33 and CDKN2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CCDC33	CDKN2B
Description		coiled-coil domain containing 33	cyclin dependent kinase inhibitor 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process		Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Nutrient Spleen Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of G0 To G1 Transition Cellular Response To Cell-matrix Adhesion Cellular Senescence Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases			Type II diabetes mellitus Osteosarcoma Malignant pleural mesothelioma
GWAS		Bacterial meningitis ( 31092817) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Hip circumference adjusted for BMI ( 34021172) Obesity-related traits ( 23251661) Systolic blood pressure ( 30578418)	Ankle-brachial index ( 22199011) Basal cell carcinoma ( 27539887 25855136 24403052) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Cataracts ( 34127677) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 23561647 22144573) Coronary artery disease ( 26708285 21239051 29212778 29263402) Coronary heart disease ( 21378990 29615537 21971053 17554300) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Cutaneous malignant melanoma ( 32341527) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Fasting blood glucose ( 33842983 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403 20512145) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Spleen volume ( 34128465) Type 2 diabetes ( 30718926 17463246 17463248 17463249 18372903 19056611 19401414 20581827 21573907 27189021 30297969 22293688 22961080 23945395 24509480 26818947 29358691 26961502) Vertical cup-disc ratio ( 20548946)
Interacting Genes		159 interacting genes: ABCF3 ABLIM3 AIRIM ANKS1A AP1M1 APP ARHGEF6 ARIH2 ARMC7 ARNT2 ATOSB BCCIP BLK BLZF1 BYSL CABP2 CALCOCO2 CCDC102B CCDC57 CCDC6 CCDC85B CCHCR1 CCNH CDC23 CDCA7L CDKN2B CENPP CFAP206 CHCHD3 CINP CIRSR CRYBA2 CRYBA4 CTNNA3 DGCR6 DIP2A DVL2 DVL3 EAF1 EFEMP2 EHMT2 EMC2 EMD ESRRG EXOC8 FAM124A FAM161A FRS3 FXR2 GCC1 GPANK1 GPATCH2L GRN GYS1 HEXIM2 HGS HNRNPF HNRNPK HOOK2 HOXA1 HSF2BP IL16 ING5 ITGB1BP1 KANK2 KCTD19 KCTD9 KDM1A KHDRBS3 KIFC3 KLHL38 KXD1 L3MBTL2 LDOC1 LMO1 LMO2 LMO3 LNX1 MAGED1 MAGOHB MAPK9 MDFI MFAP1 MID2 MIPOL1 MISP MKRN3 MLH1 MOS NAB2 NCK2 NDOR1 NECAB2 NEFL NINL NME7 OSGIN1 OSTF1 PCSK5 PID1 PIK3R3 PIN1 PLA2G6 PLSCR1 PNMA1 PNMA2 POLR1C PPP2R3C PRKAA2 PRKAB2 PRPF31 PTGER3 PTK6 QARS1 RAD51D RAD54B RBMX RHOXF2 RNF6 SCNM1 SMAD3 SMARCB1 SMARCD1 SMYD1 SPAG5 SPG21 STK16 STX11 SYT17 TASOR2 TCEANC TGFB1 TMCC2 TNS2 TRAF2 TRIM23 TRIM37 TRIM42 TRIM59 TSC22D4 TSEN15 TSGA10 TTC19 TUFT1 TXK TXLNA UBASH3A UBQLN4 USHBP1 VPS52 WT1 YES1 ZBTB8A ZGPAT ZNF330 ZNF572 ZNF688 ZNF76 ZNRD2	63 interacting genes: AKT1 APP ARAF ARNT ARPC3 ATP6V1H BECN1 CBLC CCDC33 CCDC90B CCNC CCND2 CCNE1 CD44 CDK17 CDK4 CDK6 CDK8 CDKN2C CEP126 CNKSR3 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R INCA1 ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA PICK1 PYCR3 RAF1 RASSF1 RTL8C RUSC1 SPG21 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17
Entrez ID		80125	1030
HPRD ID		09959	02696
Ensembl ID		ENSG00000140481	ENSG00000147883
Uniprot IDs		A0A1B0GV97 Q8N5R6	K7PPU3 P42772
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Cytoplasm Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process CD4 Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Neuron Maturation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Speck Spliceosomal Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Enzyme Binding	Protein Kinase Activity Regulation Of Cell Cycle Response To Growth Factor Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Signal Transduction Protein Serine Kinase Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Cellular Response To Oxygen Levels Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Population Proliferation Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of RNA Biosynthetic Process Phosphorylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?