BMP3 and COL4A2

Number of citations of the paper that reports this interaction (PMID 2211625)
13

Data Source:
HPRD (in vitro)

		BMP3	COL4A2
Gene Name		bone morphogenetic protein 3	collagen, type IV, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Collagen Type IV Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity BMP Receptor Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Skeletal System Development Ossification Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Cartilage Development SMAD Protein Signal Transduction	Angiogenesis Transcription, DNA-templated Receptor-mediated Endocytosis Axon Guidance Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways			Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS		Height ( 18391951) Pubertal anthropometrics ( 23449627) Refractive error ( 23396134)	Coronary artery calcification ( 22144573) Coronary heart disease ( 21378990)
Protein-Protein Interactions		5 interactors: COL4A1 COL4A2 KDM1A PRMT6 TGFB1	23 interactors: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FAM46A FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TGFBI TK1
Entrez ID		651	1284
HPRD ID		00208	00355
Ensembl ID		ENSG00000152785	ENSG00000134871
Uniprot IDs		P12645	P08572
PDB IDs		2QCQ	1LI1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Regulation Of DNA Binding Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Cell Development Regulation Of Neural Precursor Cell Proliferation Regulation Of Primitive Erythrocyte Differentiation Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Stem Cell Proliferation Myeloid Leukocyte Differentiation Cell Morphogenesis Involved In Differentiation Regulation Of Histone Modification Head Development Histone H3-R2 Methylation Active Induction Of Host Immune Response By Virus Nervous System Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hyaluronan Biosynthetic Process Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Regulation Of Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Cell Morphogenesis Negative Regulation Of Transcription, DNA-templated Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Retinal Blood Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Nucleic Acid-templated Transcription Morphogenesis Of A Branching Epithelium Negative Regulation Of RNA Biosynthetic Process Myeloid Cell Differentiation Morphogenesis Of A Branching Structure	Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Chemotaxis Anatomical Structure Development System Development Nervous System Development Axon Guidance Cell Morphogenesis Involved In Differentiation Hemostasis Generation Of Neurons Developmental Process Multicellular Organismal Development Neurogenesis Cell Differentiation Locomotion Extracellular Matrix Disassembly Axonogenesis Response To External Stimulus Axon Development Regulation Of Body Fluid Levels Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To Wounding Blood Coagulation Endodermal Cell Differentiation Acute-phase Response Platelet Activation Neuron Projection Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Projection Morphogenesis Cell Development Peptide Cross-linking Reproductive Process Cell Part Morphogenesis Seminal Vesicle Epithelium Development Fetal Process Involved In Parturition Dendrite Regeneration Mating Neuromuscular Junction Development Leukocyte Migration Regulation Of Pathway-restricted SMAD Protein Phosphorylation Endoderm Formation Neuron Development Collagen Catabolic Process Regulation Of Binding Behavior
Tagcloud ?		adamts17 arrays besides bioinformatics causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic prkg2 rodents segregating segregation short shox stature trait tulp4	13q33 bptf d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Difference) ?		adamts17 arrays besides bioinformatics causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic prkg2 rodents segregating segregation short shox stature trait tulp4	13q33 bptf d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Intersection) ?