BMP3

Gene Name		bone morphogenetic protein 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity BMP Receptor Binding
	Biological Process	Skeletal System Development Ossification Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Cartilage Development SMAD Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS		Height ( 18391951) Pubertal anthropometrics ( 23449627) Refractive error ( 23396134)
Protein-protein Interactions		5 interactors: COL4A1 COL4A2 KDM1A PRMT6 TGFB1
Entrez ID		651
HPRD ID		00208
Ensembl ID		ENSG00000152785
Uniprot IDs		P12645
PDB IDs		2QCQ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Regulation Of DNA Binding Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Cell Development Regulation Of Neural Precursor Cell Proliferation Regulation Of Primitive Erythrocyte Differentiation Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Stem Cell Proliferation Myeloid Leukocyte Differentiation Cell Morphogenesis Involved In Differentiation Regulation Of Histone Modification Head Development Histone H3-R2 Methylation Active Induction Of Host Immune Response By Virus Nervous System Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hyaluronan Biosynthetic Process Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Regulation Of Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Cell Morphogenesis Negative Regulation Of Transcription, DNA-templated Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Retinal Blood Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Nucleic Acid-templated Transcription Morphogenesis Of A Branching Epithelium Negative Regulation Of RNA Biosynthetic Process Myeloid Cell Differentiation Morphogenesis Of A Branching Structure
Tagcloud ?		adamts17 arrays besides bioinformatics causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic prkg2 rodents segregating segregation short shox stature trait tulp4