RHBDF1 and TGFA

Number of citations of the paper that reports this interaction (PubMedID 15965977)
0

Data Source:
HPRD (in vitro, in vivo)

		RHBDF1	TGFA
Description		rhomboid 5 homolog 1	transforming growth factor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endomembrane System Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Binding	Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Cell Population Proliferation Protein Transport Cell Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Regulation Of Proteasomal Protein Catabolic Process	Angiogenesis Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Intracellular Signal Transduction ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Mammary Gland Alveolus Development Hepatocyte Proliferation
Pathways			PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Gastric cancer
GWAS		Alzheimer's disease (late onset) ( 28714976) Body mass index ( 26426971) Glioma ( 29743610) Non-glioblastoma glioma ( 29743610)	Acne (severe) ( 24927181) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Hair shape ( 29220522) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Longevity ( 20834067) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Osteoarthritis ( 30664745) Pulse pressure in young-onset hypertension ( 24892410) Response to citalopram or escitalopram in depression ( 27622933) Response to esketamine in treatment resistant depression ( 32724131) Severe progression in rheumatoid arthritis ( 29065906) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		2 interacting genes: LHX3 TGFA	17 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 LEPROTL1 MAGI2 MAGI3 NKD2 RHBDD1 RHBDF1 SDCBP SGTA SNTA1
Entrez ID		64285	7039
HPRD ID		07027	07522
Ensembl ID		ENSG00000007384	ENSG00000163235
Uniprot IDs		Q96CC6	E7EPT6 F8VNR3 P01135
PDB IDs			1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5 7SZ5 7SZ7
Enriched GO Terms of Interacting Partners?		Hepatocyte Proliferation Medial Motor Column Neuron Differentiation Ventral Spinal Cord Interneuron Specification Thyroid-stimulating Hormone-secreting Cell Differentiation Spinal Cord Motor Neuron Cell Fate Specification Prolactin Secreting Cell Differentiation Somatotropin Secreting Cell Differentiation ERBB2-EGFR Signaling Pathway Spinal Cord Association Neuron Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Mammary Gland Alveolus Development Neuroendocrine Cell Differentiation ERBB2 Signaling Pathway Glandular Epithelial Cell Differentiation Motor Neuron Axon Guidance Neuron Fate Specification Pituitary Gland Development Epidermal Growth Factor Receptor Binding Forebrain Neuron Differentiation Neuroepithelial Cell Differentiation Cell Differentiation In Spinal Cord Transcription Coregulator Binding Placenta Development Positive Regulation Of Mitotic Nuclear Division Transcription Coactivator Binding ER To Golgi Transport Vesicle Membrane Inner Ear Development Epidermal Growth Factor Receptor Signaling Pathway Dorsal/ventral Pattern Formation Clathrin-coated Endocytic Vesicle Membrane ERBB Signaling Pathway Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Fate Specification Positive Regulation Of Cell Division Lung Development	Localization Within Membrane Positive Regulation Of Growth Positive Regulation Of Cell Growth Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endopeptidase Activity Establishment Of Protein Localization To Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Membrane Membrane Protein Proteolysis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cell Migration Regulation Of Signal Transduction Golgi Membrane Regulation Of Protein Catabolic Process Metallodipeptidase Activity ERBB2-EGFR Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Growth ERBB4 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neuromuscular Junction Positive Regulation Of Protein Phosphorylation ATPase Binding Regulation Of Cell Communication Regulation Of Signaling Basolateral Plasma Membrane Positive Regulation Of T Cell Chemotaxis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of T Cell Chemotaxis
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