OLFM4 and EREG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OLFM4	EREG
Description		olfactomedin 4	epiregulin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Cadherin Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Immune Response Cell Adhesion Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Immune Response Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Angiogenesis Ovarian Cumulus Expansion Oocyte Maturation Positive Regulation Of Cytokine Production Female Meiotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation MRNA Transcription Anatomical Structure Morphogenesis Animal Organ Morphogenesis Cytokine-mediated Signaling Pathway Cell Differentiation Keratinocyte Differentiation Ovulation Positive Regulation Of Interleukin-6 Production ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Phosphorylation Luteinizing Hormone Signaling Pathway Response To Peptide Hormone Keratinocyte Proliferation Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Fibroblast Proliferation Primary Follicle Stage Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division
Pathways		Neutrophil degranulation	Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413 25953783 28448500 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	Attention deficit hyperactivity disorder ( 18821565) Breast size ( 22747683) Metabolite levels ( 22916037)
Interacting Genes		36 interacting genes: APP AQP2 AQP3 BSCL2 C3 CFTR CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PVR PVRIG QPCTL SAR1A SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18	7 interacting genes: CFTR CXCL9 EGFR ERBB4 MS4A13 NINJ2 OLFM4
Entrez ID		10562	2069
HPRD ID		06580	03638
Ensembl ID		ENSG00000102837	ENSG00000124882
Uniprot IDs		Q6UX06	O14944
PDB IDs			1K36 1K37 5E8D 5WB7 7LEN 7LFR 7LFS 8HGP
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Ligand Activity Multicellular Organismal-level Chemical Homeostasis Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Glycerol Transmembrane Transport Multicellular Organismal-level Homeostasis Renal Water Transport Polyol Transmembrane Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Yeast Cell Maturation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Neuron Remodeling Water Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Defense Response Cell Surface Regulation Of Immune System Process Renal Water Homeostasis	Epidermal Growth Factor Receptor Activity ERBB2 Signaling Pathway Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Protein Localization Cellular Response To Lipid Positive Regulation Of Anion Channel Activity Shc-EGFR Complex Central Nervous System Morphogenesis Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Protein Kinase C Signaling Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Regeneration Positive Regulation Of Enamel Mineralization Epidermal Growth Factor Binding Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Membrane Destabilizing Activity Plasma Membrane Transepithelial Water Transport Regulation Of Protein Kinase C Signaling ERBB2-ERBB4 Signaling Pathway CXCR3 Chemokine Receptor Binding Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Protein-containing Complex Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade ERBB4-ERBB4 Signaling Pathway
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