OLFM4 and IL11RA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OLFM4	IL11RA
Description		olfactomedin 4	interleukin 11 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Structural Molecule Activity Protein Binding Cadherin Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-11 Receptor Activity Protein Binding Interleukin-11 Binding
	Biological Process	Immune Response Cell Adhesion Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Immune Response Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Embryo Implantation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Developmental Process Interleukin-11-mediated Signaling Pathway Head Development
Pathways		Neutrophil degranulation	IL-6-type cytokine receptor ligand interactions
Drugs			Oprelvekin
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413 25953783 28448500 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	CTACK levels ( 27989323)
Interacting Genes		36 interacting genes: APP AQP2 AQP3 BSCL2 C3 CFTR CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PVR PVRIG QPCTL SAR1A SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18	3 interacting genes: IL11 OLFM4 USP40
Entrez ID		10562	3590
HPRD ID		06580	02965
Ensembl ID		ENSG00000102837	ENSG00000137070
Uniprot IDs		Q6UX06	Q14626
PDB IDs			6O4P 8DPS 8DPT 8DPU 8QY4
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Ligand Activity Multicellular Organismal-level Chemical Homeostasis Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Glycerol Transmembrane Transport Multicellular Organismal-level Homeostasis Renal Water Transport Polyol Transmembrane Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Yeast Cell Maturation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Neuron Remodeling Water Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Defense Response Cell Surface Regulation Of Immune System Process Renal Water Homeostasis	Interleukin-11 Receptor Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cytokine Activity Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Cell-substrate Adhesion Interleukin-11-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Complement-dependent Cytotoxicity Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Immunological Synapse Formation Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of Canonical NF-kappaB Signal Transduction Chemokine Receptor Binding Establishment Of T Cell Polarity Negative Regulation Of Cellular Extravasation Azurophil Granule Specific Granule Regulation Of Leukocyte Tethering Or Rolling Regulation Of T Cell Chemotaxis Cellular Response To Chemokine Dendritic Cell Chemotaxis Cytokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Lymphocyte Chemotaxis
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