OLFM4 and SLC22A23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OLFM4	SLC22A23
Description		olfactomedin 4	solute carrier family 22 member 23
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen	Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Cadherin Binding	Protein Binding Transmembrane Transporter Activity
	Biological Process	Immune Response Cell Adhesion Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Immune Response Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Monoatomic Ion Transport Transmembrane Transport
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413 25953783 28448500 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	Antipsychotic drug-induced QTc interval prolongation ( 20921969) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting insulin (dietary factor interaction) ( 24204828) General cognitive ability ( 29844566) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 27863252 32888494) Nicotine dependence ( 28440896) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Red cell distribution width ( 27863252 28957414 32888494) Refractive error ( 32231278) Survival in rectal cancer ( 25866641)
Interacting Genes		36 interacting genes: APP AQP2 AQP3 BSCL2 C3 CFTR CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PVR PVRIG QPCTL SAR1A SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18	17 interacting genes: ADAM33 ADIPOQ CBLIF CLCA4 CLN6 CNIH1 ERMP1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MEOX2 NOTCH2NLA OLFM4 PSMA3 PTTG1IP UPK2 WFDC2
Entrez ID		10562	63027
HPRD ID		06580	12904
Ensembl ID		ENSG00000102837	ENSG00000137266
Uniprot IDs		Q6UX06	A1A5C7 C9J4Z0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Ligand Activity Multicellular Organismal-level Chemical Homeostasis Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Glycerol Transmembrane Transport Multicellular Organismal-level Homeostasis Renal Water Transport Polyol Transmembrane Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Yeast Cell Maturation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Neuron Remodeling Water Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Defense Response Cell Surface Regulation Of Immune System Process Renal Water Homeostasis
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