TFPI and MMP1

Number of citations of the paper that reports this interaction (PMID 10859319)
17

Data Source:
HPRD (in vitro)

		TFPI	MMP1
Gene Name		tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	matrix metallopeptidase 1 (interstitial collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Organelle Membrane Anchored Component Of Membrane	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall
Drugs		Coagulation factor VIIa Dalteparin	Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		10 interactors: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1	17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		7035	4312
HPRD ID		01064	00384
Ensembl ID		ENSG00000003436	ENSG00000196611
Uniprot IDs		P10646	B4DN15 P03956 Q53G95
PDB IDs		1ADZ 1IRH 1TFX 4DTG	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Proteolysis Locomotion Cell Migration Movement Of Cell Or Subcellular Component Protein Metabolic Process Cell Motility Wound Healing Response To Wounding Immune System Process Response To Stress Blood Coagulation Hemostasis Catabolic Process Negative Regulation Of Chemotaxis Regulation Of Body Fluid Levels Immune Response Leukocyte Migration Defense Response Endodermal Cell Differentiation Regulation Of Locomotion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Biosynthetic Process Platelet Degranulation Negative Regulation Of CGMP-mediated Signaling Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Response To External Stimulus Positive Regulation Of Protein Kinase B Signaling Response To Stimulus Positive Regulation Of Epithelial Cell Migration Endoderm Development Negative Regulation Of Ion Transport Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Fungus Regulation Of Cytokine Biosynthetic Process Regulation Of Protein Kinase B Signaling	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis
Tagcloud ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?