TFPI and MMP1

Number of citations of the paper that reports this interaction (PubMedID 10859319)
0

Data Source:
HPRD (in vitro)

		TFPI	MMP1
Description		tissue factor pathway inhibitor	matrix metallopeptidase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Membrane Side Of Membrane	Extracellular Region Extracellular Matrix
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Cellular Response To Steroid Hormone Stimulus Cellular Response To Lipid	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV-A
Pathways		Extrinsic Pathway of Fibrin Clot Formation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling
Drugs		IIa Recombinant Human Dalteparin Andexanet alfa	Marimastat CGS-27023 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases			Choriocarcinoma
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1	17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		7035	4312
HPRD ID		01064	00384
Ensembl ID		ENSG00000003436	ENSG00000196611
Uniprot IDs		P10646	B4DN15 P03956 Q53G95
PDB IDs		1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8 7V1N	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Activity Extracellular Matrix Disassembly Endopeptidase Activity Extracellular Matrix Organization Extracellular Structure Organization Peptidase Activity Collagen Catabolic Process Collagen Metabolic Process Extracellular Matrix Extracellular Region Metalloendopeptidase Activity Extracellular Space Metallopeptidase Activity Protein Metabolic Process Proteolysis Hydrolase Activity Antibacterial Peptide Biosynthetic Process Response To External Biotic Stimulus Macromolecule Metabolic Process Tertiary Granule Lumen Positive Regulation Of Cytokine Production Regulation Of Cell Migration Response To Amyloid-beta Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cellular Response To UV-A Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Phosphate Metabolic Process Response To Light Stimulus Response To UV-A Positive Regulation Of Tumor Necrosis Factor Production Response To Yeast Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Serine-type Peptidase Activity Regulation Of Cytokine Production Platelet Alpha Granule Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Smooth Muscle Cell Proliferation Peptide Biosynthetic Process Cell Migration Response To Radiation Response To UV Heparin Binding	Extracellular Space Extracellular Region Extracellular Matrix Myeloid Leukocyte Migration Leukocyte Chemotaxis Hyaluronic Acid Binding Granulocyte Migration Cell Chemotaxis Regulation Of Cell Migration Cell Migration Granulocyte Chemotaxis Cytokine Activity Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Regulation Of Cell Motility Leukocyte Migration CCR Chemokine Receptor Binding Cell Motility Regulation Of Locomotion CCR2 Chemokine Receptor Binding Animal Organ Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Chemotaxis Chemokine Activity Positive Regulation Of Locomotion Locomotion Cytokine-mediated Signaling Pathway Perineuronal Net Chemokine-mediated Signaling Pathway Regulation Of Cell Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Homeostatic Process Inflammatory Response Cartilage Development Mononuclear Cell Migration Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Apoptotic Process Regulation Of Lymphocyte Chemotaxis Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Cell Shape Positive Regulation Of Chemotaxis Central Nervous System Development
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