TFPI and MMP12

Number of citations of the paper that reports this interaction (PMID 10859319)
17

Data Source:
HPRD (in vitro)

		TFPI	MMP12
Gene Name		tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	matrix metallopeptidase 12 (macrophage elastase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Organelle Membrane Anchored Component Of Membrane	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Pathways		Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Collagen degradation Degradation of the extracellular matrix
Drugs		Coagulation factor VIIa Dalteparin	Acetohydroxamic Acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4\'-Ethoxy-1,1\'-Biphenyl-4-Yl)-4-Oxobutanoic Acid (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine
Diseases
GWAS		Heart rate ( 23583979)	Alzheimer's disease ( 22832961)
Protein-Protein Interactions		10 interactors: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1	5 interactors: APP F12 LPA PLAUR TFPI
Entrez ID		7035	4321
HPRD ID		01064	03027
Ensembl ID		ENSG00000003436
Uniprot IDs		P10646	P39900
PDB IDs		1ADZ 1IRH 1TFX 4DTG	1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Proteolysis Locomotion Cell Migration Movement Of Cell Or Subcellular Component Protein Metabolic Process Cell Motility Wound Healing Response To Wounding Immune System Process Response To Stress Blood Coagulation Hemostasis Catabolic Process Negative Regulation Of Chemotaxis Regulation Of Body Fluid Levels Immune Response Leukocyte Migration Defense Response Endodermal Cell Differentiation Regulation Of Locomotion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Biosynthetic Process Platelet Degranulation Negative Regulation Of CGMP-mediated Signaling Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Response To External Stimulus Positive Regulation Of Protein Kinase B Signaling Response To Stimulus Positive Regulation Of Epithelial Cell Migration Endoderm Development Negative Regulation Of Ion Transport Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Fungus Regulation Of Cytokine Biosynthetic Process Regulation Of Protein Kinase B Signaling	Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Urokinase Plasminogen Activator Signaling Pathway Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Factor XII Activation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Protein Activation Cascade Lipoprotein Metabolic Process Collateral Sprouting In Absence Of Injury Protein Metabolic Process Positive Regulation Of Fibrinolysis Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Plasminogen Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Lipid Metabolic Process Neuron Remodeling Response To Stress Protein Autoprocessing Plasma Kallikrein-kinin Cascade Attachment Of GPI Anchor To Protein Regulation Of Fibrinolysis Regulation Of Metabolic Process Blood Coagulation, Intrinsic Pathway Response To Misfolded Protein Cellular Copper Ion Homeostasis Positive Regulation Of Protein Processing
Tagcloud ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic	2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin tumorigenesis worldwide yl
Tagcloud (Difference) ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic	2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin tumorigenesis worldwide yl
Tagcloud (Intersection) ?