TFPI and MMP8

Number of citations of the paper that reports this interaction (PMID 12117418)
8

Data Source:
HPRD (in vitro)

		TFPI	MMP8
Gene Name		tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	matrix metallopeptidase 8 (neutrophil collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Organelle Membrane Anchored Component Of Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways		Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Coagulation factor VIIa Dalteparin	Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione Glycinamid Batimastat N-{2-[(4\'-CYANO-1,1\'-BIPHENYL-4-YL)OXY]ETHYL}-N\'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID (1R)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Heart rate ( 23583979)	Prostate cancer ( 23535732)
Protein-Protein Interactions		10 interactors: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1	7 interactors: ACAN BCAN CCL2 TFPI TIMP2 UBC UMOD
Entrez ID		7035	4317
HPRD ID		01064	00385
Ensembl ID		ENSG00000003436	ENSG00000118113
Uniprot IDs		P10646	P22894
PDB IDs		1ADZ 1IRH 1TFX 4DTG	1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Proteolysis Locomotion Cell Migration Movement Of Cell Or Subcellular Component Protein Metabolic Process Cell Motility Wound Healing Response To Wounding Immune System Process Response To Stress Blood Coagulation Hemostasis Catabolic Process Negative Regulation Of Chemotaxis Regulation Of Body Fluid Levels Immune Response Leukocyte Migration Defense Response Endodermal Cell Differentiation Regulation Of Locomotion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Biosynthetic Process Platelet Degranulation Negative Regulation Of CGMP-mediated Signaling Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Response To External Stimulus Positive Regulation Of Protein Kinase B Signaling Response To Stimulus Positive Regulation Of Epithelial Cell Migration Endoderm Development Negative Regulation Of Ion Transport Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Fungus Regulation Of Cytokine Biosynthetic Process Regulation Of Protein Kinase B Signaling	Extracellular Matrix Disassembly Pathogenesis Neutrophil Migration Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Response To Vitamin B3 Helper T Cell Extravasation Negative Regulation Of Natural Killer Cell Chemotaxis Cellular Response To High Density Lipoprotein Particle Stimulus Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Metanephric Thick Ascending Limb Development Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Response To High Density Lipoprotein Particle Negative Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Metanephric Ascending Thin Limb Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Viral Life Cycle Regulation Of Cellular Protein Metabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Blood Coagulation, Extrinsic Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Mitotic Cell Cycle Leukocyte Migration MAPK Cascade Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Central Nervous System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Astrocyte Cell Migration Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of Apoptotic Cell Clearance
Tagcloud ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Difference) ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Intersection) ?