TFPI

Gene Name		tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Organelle Membrane Anchored Component Of Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity
Pathways		Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Coagulation factor VIIa Dalteparin
Diseases
GWAS		Heart rate ( 23583979)
Protein-protein Interactions		10 interactors: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		7035
HPRD ID		01064
Ensembl ID		ENSG00000003436
Uniprot IDs		P10646
PDB IDs		1ADZ 1IRH 1TFX 4DTG
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Proteolysis Locomotion Cell Migration Movement Of Cell Or Subcellular Component Protein Metabolic Process Cell Motility Wound Healing Response To Wounding Immune System Process Response To Stress Blood Coagulation Hemostasis Catabolic Process Negative Regulation Of Chemotaxis Regulation Of Body Fluid Levels Immune Response Leukocyte Migration Defense Response Endodermal Cell Differentiation Regulation Of Locomotion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Biosynthetic Process Platelet Degranulation Negative Regulation Of CGMP-mediated Signaling Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Response To External Stimulus Positive Regulation Of Protein Kinase B Signaling Response To Stimulus Positive Regulation Of Epithelial Cell Migration Endoderm Development Negative Regulation Of Ion Transport Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Fungus Regulation Of Cytokine Biosynthetic Process Regulation Of Protein Kinase B Signaling
Tagcloud ?		antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic