TFPI

Description		tissue factor pathway inhibitor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Membrane Side Of Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Cellular Response To Steroid Hormone Stimulus Cellular Response To Lipid
Pathways		Extrinsic Pathway of Fibrin Clot Formation
Drugs		IIa Recombinant Human Dalteparin Andexanet alfa
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		7035
HPRD ID		01064
Ensembl ID		ENSG00000003436
Uniprot IDs		P10646
PDB IDs		1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8 7V1N
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Activity Extracellular Matrix Disassembly Endopeptidase Activity Extracellular Matrix Organization Extracellular Structure Organization Peptidase Activity Collagen Catabolic Process Collagen Metabolic Process Extracellular Matrix Extracellular Region Metalloendopeptidase Activity Extracellular Space Metallopeptidase Activity Protein Metabolic Process Proteolysis Hydrolase Activity Antibacterial Peptide Biosynthetic Process Response To External Biotic Stimulus Macromolecule Metabolic Process Tertiary Granule Lumen Positive Regulation Of Cytokine Production Regulation Of Cell Migration Response To Amyloid-beta Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cellular Response To UV-A Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Phosphate Metabolic Process Response To Light Stimulus Response To UV-A Positive Regulation Of Tumor Necrosis Factor Production Response To Yeast Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Serine-type Peptidase Activity Regulation Of Cytokine Production Platelet Alpha Granule Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Smooth Muscle Cell Proliferation Peptide Biosynthetic Process Cell Migration Response To Radiation Response To UV Heparin Binding
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