TFE3 and MITF

Number of citations of the paper that reports this interaction (PMID 11930005)
32

Data Source:
HPRD (in vivo)

		TFE3	MITF
Gene Name		transcription factor binding to IGHM enhancer 3	microphthalmia-associated transcription factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Protein Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Humoral Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: E2F3 HMGB1 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG	28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I
Entrez ID		7030	4286
HPRD ID		02439	01138
Ensembl ID		ENSG00000068323	ENSG00000187098
Uniprot IDs		B4DIA5 P19532 Q5JU74	B4DNC7 O75030 Q8WYR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process SMAD Protein Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression RNA Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Intracellular Transport Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter System Development Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Somitogenesis Anatomical Structure Development Endoderm Development Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Embryonic Pattern Specification Cellular Nitrogen Compound Metabolic Process Regulation Of Intracellular Transport	Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		aas adopt amphipathic bhlh caf cbp cbp2 cofactor confirming e1a fos fused genesis helical helix immunoprecipitate leucine lz melanocyte melanocytes mi microphthalmia myod parallels pigment potentiated resides vp16 zipper	agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase
Tagcloud (Difference) ?		aas adopt amphipathic bhlh caf cbp cbp2 cofactor confirming e1a fos fused genesis helical helix immunoprecipitate leucine lz melanocyte melanocytes mi myod parallels pigment potentiated resides vp16 zipper	agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase
Tagcloud (Intersection) ?		microphthalmia