TFE3 and TFEB

Number of citations of the paper that reports this interaction (PMID 9806910)
25

Data Source:
HPRD (in vivo)

		TFE3	TFEB
Gene Name		transcription factor binding to IGHM enhancer 3	transcription factor EB
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Protein Dimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Humoral Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter	Embryonic Placenta Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Autophagy Humoral Immune Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		9 interactors: E2F3 HMGB1 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG	4 interactors: MITF SRPK1 TFE3 TFEC
Entrez ID		7030	7942
HPRD ID		02439	02847
Ensembl ID		ENSG00000068323	ENSG00000112561
Uniprot IDs		B4DIA5 P19532 Q5JU74	B0QYS6 P19484
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process SMAD Protein Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression RNA Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Intracellular Transport Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter System Development Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Somitogenesis Anatomical Structure Development Endoderm Development Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Apoptotic Cell Clearance Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Embryonic Pattern Specification Cellular Nitrogen Compound Metabolic Process Regulation Of Intracellular Transport	Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Regulation Of Myeloid Cell Differentiation RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Sperm Chromatin Condensation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immune System Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Viral Genome Replication RNA Biosynthetic Process Spermatid Nucleus Differentiation Melanocyte Differentiation Osteoclast Differentiation Negative Regulation Of Viral Genome Replication Neuroepithelial Cell Differentiation Bone Remodeling Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Developmental Pigmentation Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Viral Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Regulation Of MRNA Processing Canonical Wnt Signaling Pathway Immune Response Regulation Of Immune System Process Regulation Of RNA Splicing Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Response To Heat Tissue Remodeling Myeloid Leukocyte Differentiation Pigmentation Nucleus Organization
Tagcloud ?		aas adopt amphipathic bhlh caf cbp cbp2 cofactor confirming e1a fos fused genesis helical helix immunoprecipitate leucine lz melanocyte melanocytes mi microphthalmia myod parallels pigment potentiated resides vp16 zipper	adaptors alters axonally delays endosomal enlarged enlarges fatal fronto ftld highlighting illumination lamp lobar lumenal lysosomal lysosomes organelle photodamage reporters soma sted tdp tmem106 tmem106b torin traffic transported yields
Tagcloud (Difference) ?		aas adopt amphipathic bhlh caf cbp cbp2 cofactor confirming e1a fos fused genesis helical helix immunoprecipitate leucine lz melanocyte melanocytes mi microphthalmia myod parallels pigment potentiated resides vp16 zipper	adaptors alters axonally delays endosomal enlarged enlarges fatal fronto ftld highlighting illumination lamp lobar lumenal lysosomal lysosomes organelle photodamage reporters soma sted tdp tmem106 tmem106b torin traffic transported yields
Tagcloud (Intersection) ?