IL17RA and BID

		IL17RA	BID
Description		interleukin 17 receptor A	BH3 interacting domain death agonist
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Interleukin-17 Receptor Activity	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process
	Biological Process	Adaptive Immune Response Immune System Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Virus Protein Catabolic Process Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-17A-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Granulocyte Chemotaxis Fibroblast Activation T-helper 17 Type Immune Response Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Stress Intracellular Signal Transduction Regulation Of T Cell Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Supramolecular Fiber Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-17 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 27863252 32888494)	Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		2 interacting genes: IL17A MTDH	36 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		23765	637
HPRD ID		10399	03590
Ensembl ID		ENSG00000177663	ENSG00000015475
Uniprot IDs		Q96F46	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs		3JVF 4HSA 4NUX 5N9B 5NAN 7UWL 7UWM 7UWN 7ZAN	1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F 7M5A 7M5B 7P33 7QTW 8SM5
Enriched GO Terms of Interacting Partners?			Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Release Of Cytochrome C From Mitochondria Apoptotic Process Cell Death Programmed Cell Death Channel Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Execution Phase Of Apoptosis Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Protein Kinase CK2 Complex Mitochondrial Outer Membrane Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Protein Maturation Regulation Of Programmed Cell Death Identical Protein Binding Leukocyte Apoptotic Process DNA Damage Response Regulation Of Neuron Apoptotic Process Mitochondrial Fusion Negative Regulation Of Anoikis Regulation Of Autophagy Signal Transduction Programmed Cell Death Involved In Cell Development Response To Cytokine Response To Peptide Negative Regulation Of Programmed Cell Death Regulation Of Anoikis Cysteine-type Endopeptidase Activity Peptidase Activity B Cell Homeostasis Cytosol Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Mitochondrion Organization Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Response To Stress B Cell Apoptotic Process Pyroptotic Inflammatory Response
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