EIF4B and USP11

Number of citations of the paper that reports this interaction (PubMedID 29483509)
68

Data Source:
BioGRID (enzymatic study)

		EIF4B	USP11
Description		eukaryotic translation initiation factor 4B	ubiquitin specific peptidase 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly	Proteolysis Protein Deubiquitination
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)
Interacting Genes		20 interacting genes: ACD CASP3 CEBPA CSNK2A1 EIF3A EIF4E LAMTOR5 LINC01554 PABPC1 PAK2 POT1 PRKN RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11	26 interacting genes: BMI1 BRCA2 CBX8 DECR2 DSCAM EIF4B HELLS LIMS1 LLGL1 MBD3 MTA2 NFE2L2 NONO PCGF2 PML PRMT1 PROM1 RANBP9 RELB RNF2 RPS6KB1 RSPH1 SETDB1 SUMO2 TBL3 UBC
Entrez ID		1975	8237
HPRD ID		04892	02081
Ensembl ID		ENSG00000063046	ENSG00000102226
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0	G5E9A6
PDB IDs		1WI8 2J76 6FEC
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Response To Glucocorticoid Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Response To Corticosteroid Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Organelle Organization Regulation Of Telomere Maintenance Positive Regulation Of Macromolecule Metabolic Process Telomere Organization Intracellular Signal Transduction Regulation Of Cell Cycle Response To Dexamethasone Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization Positive Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Metabolic Process DEAD/H-box RNA Helicase Binding Regulation Of Macromolecule Biosynthetic Process Nucleus	Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Nucleoplasm Negative Regulation Of Apoptotic Signaling Pathway Heterochromatin Regulation Of Apoptotic Signaling Pathway Constitutive Heterochromatin Formation Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Chordate Embryonic Development Cellular Response To Methionine Regulation Of DNA-templated Transcription Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Nucleus Response To Methionine Sex Chromatin Regulation Of RNA Biosynthetic Process Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Cytokine Cellular Response To Hydrogen Peroxide Response To Peptide Promoter-specific Chromatin Binding Camera-type Eye Photoreceptor Cell Differentiation Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound
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