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EIF4B
Gene Name
eukaryotic translation initiation factor 4B
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 4F Complex
Molecular Function
Nucleotide Binding
RNA Binding
Translation Initiation Factor Activity
Protein Binding
Poly(A) RNA Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Translation
Translational Initiation
Regulation Of Translational Initiation
Insulin Receptor Signaling Pathway
Gene Expression
Cellular Protein Metabolic Process
Pathways
Translation initiation complex formation
IRS-mediated signalling
mTOR signalling
S6K1-mediated signalling
mTOR signalling
mTORC1-mediated signalling
IGF1R signaling cascade
Deadenylation-dependent mRNA decay
IRS-related events triggered by IGF1R
Eukaryotic Translation Initiation
S6K1 signalling
Cap-dependent Translation Initiation
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Insulin receptor signalling cascade
Deadenylation of mRNA
Translation
S6K1 signalling
IRS-related events
L13a-mediated translational silencing of Ceruloplasmin expression
S6K1-mediated signalling
mTORC1-mediated signalling
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
PKB-mediated events
PI3K Cascade
Drugs
Diseases
GWAS
Prostate cancer (
21743057
)
Protein-protein Interactions
12 interactors:
ACD
CASP3
CSNK2A1
EIF3A
EIF4E
PABPC1
PAK2
POT1
RPS6KB1
SFN
TERF1
TINF2
Entrez ID
1975
HPRD ID
04892
Ensembl ID
ENSG00000063046
Uniprot IDs
B4DS13
E7EX17
P23588
PDB IDs
1WI8
2J76
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance
Negative Regulation Of Chromosome Organization
Telomere Assembly
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of DNA Replication
Telomere Maintenance
Regulation Of Chromosome Organization
Regulation Of Telomerase Activity
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of Transferase Activity
Regulation Of DNA Replication
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of DNA Biosynthetic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Organelle Organization
Regulation Of Cell Cycle
Regulation Of Cysteine-type Endopeptidase Activity
Protein Localization To Chromosome, Telomeric Region
Telomere Capping
Positive Regulation Of Telomerase Activity
Regulation Of Translation
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomerase Activity
Regulation Of Proteolysis
Positive Regulation Of Telomere Maintenance
Regulation Of Cellular Component Organization
Mitotic Cell Cycle
Negative Regulation Of Proteolysis
Homeostatic Process
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Regulation Of Apoptotic Process
Positive Regulation Of Organelle Organization
Regulation Of Protein Processing
Regulation Of Mitotic Cell Cycle
Regulation Of Peptidase Activity
Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Tagcloud
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43s
48s
4a
4f
assumed
cap
capped
codon
coherent
description
dissociate
eif1
eif1a
eif4a
eif4f
exclusively
incubated
individually
initiation
mediate
messenger
preinitiation
reach
ribosomal
ribosomes
synergistically
unable
weakly