PPP1R11 and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPP1R11	PPP1CB
Description		protein phosphatase 1 regulatory inhibitor subunit 11	protein phosphatase 1 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Transferase Activity Phosphatase Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity
	Biological Process	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Defense Response To Gram-positive Bacterium	MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Rhythmic Process Cell Division
Pathways			Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Lipid metabolism phenotypes ( 22286219)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 28869591 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		10 interacting genes: AKT1 IFT20 LATS1 PPP1CA PPP1CB PPP1CC PPP1R3A UBXN2B VCP YAF2	46 interacting genes: ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NONO PHACTR3 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP2R5C PRKAR2A PTK2 RB1 RORC SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9
Entrez ID		6992	5500
HPRD ID		09449	11792
Ensembl ID		ENSG00000204619	ENSG00000213639
Uniprot IDs		A2BEK1 O60927	P62140 V9HW04
PDB IDs		8DWK 8DWL 8U5G
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Response To Radiation Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Biosynthetic Process Response To Light Stimulus Circadian Rhythm Regulation Of Glycogen Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Protein Localization Positive Regulation Of Cellular Component Biogenesis Circadian Regulation Of Gene Expression Postsynapse Regulation Of Organelle Assembly Glutamatergic Synapse Regulation Of Canonical Wnt Signaling Pathway Rhythmic Process Phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Assembly Regulation Of Synapse Organization Protein Phosphatase Type 1 Complex Regulation Of Translational Initiation Regulation Of Wnt Signaling Pathway Regulation Of Small Molecule Metabolic Process Regulation Of Circadian Rhythm Positive Regulation Of Glycogen Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Cell Surface Regulation Of Proteolysis Dephosphorylation Phosphate-containing Compound Metabolic Process Phosphoprotein Phosphatase Activity Regulation Of Oxidative Phosphorylation Positive Regulation Of Glial Cell Proliferation Intracellular Signaling Cassette Negative Regulation Of Lipid Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway	Myosin Phosphatase Regulator Activity Protein Phosphatase Inhibitor Activity Phosphatase Regulator Activity Protein Phosphatase 1 Binding Glycogen Binding Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Phosphatase Binding Enzyme Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Glycogen Biosynthetic Process Stress Fiber Regulation Of Centromere Complex Assembly Regulation Of Glycogen Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Kinase Binding Centrosome Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromatin Cell Projection Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle A Band Segment Specification Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Process
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