PPP1R11 and UBXN2B

Number of citations of the paper that reports this interaction (PubMedID 33058883)
0

Data Source:
BioGRID (pull down)

		PPP1R11	UBXN2B
Description		protein phosphatase 1 regulatory inhibitor subunit 11	UBX domain protein 2B
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Spindle Pole Centrosome
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Transferase Activity Phosphatase Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Defense Response To Gram-positive Bacterium	Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways
Drugs
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Lipid metabolism phenotypes ( 22286219)	Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		10 interacting genes: AKT1 IFT20 LATS1 PPP1CA PPP1CB PPP1CC PPP1R3A UBXN2B VCP YAF2	16 interacting genes: CRX INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 PPP1R3A PPP1R7 UBC UBXN6 VAT1L VCP XAF1
Entrez ID		6992	137886
HPRD ID		09449	18973
Ensembl ID		ENSG00000204619	ENSG00000215114
Uniprot IDs		A2BEK1 O60927	E5RJ36 Q14CS0
PDB IDs		8DWK 8DWL 8U5G	8B5R
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Response To Radiation Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Biosynthetic Process Response To Light Stimulus Circadian Rhythm Regulation Of Glycogen Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Protein Localization Positive Regulation Of Cellular Component Biogenesis Circadian Regulation Of Gene Expression Postsynapse Regulation Of Organelle Assembly Glutamatergic Synapse Regulation Of Canonical Wnt Signaling Pathway Rhythmic Process Phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Assembly Regulation Of Synapse Organization Protein Phosphatase Type 1 Complex Regulation Of Translational Initiation Regulation Of Wnt Signaling Pathway Regulation Of Small Molecule Metabolic Process Regulation Of Circadian Rhythm Positive Regulation Of Glycogen Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Localization To Cell Surface Regulation Of Proteolysis Dephosphorylation Phosphate-containing Compound Metabolic Process Phosphoprotein Phosphatase Activity Regulation Of Oxidative Phosphorylation Positive Regulation Of Glial Cell Proliferation Intracellular Signaling Cassette Negative Regulation Of Lipid Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway	Somite Specification Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus HMG Box Domain Binding Segment Specification Somite Development DNA-binding Transcription Factor Activity Protein Phosphatase 1 Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Cis-trans Isomerase Activity Flavin Adenine Dinucleotide Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Retina Development In Camera-type Eye Sclerotome Development Embryonic Pattern Specification Cerebral Cortex Development Habenula Development Pallium Development Ubiquitin Protein Ligase Binding Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Modification-dependent Protein Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Endosome To Lysosome Transport Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Proteolysis Cytoplasm Protein Quality Control ERAD Pathway
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