SS18L1 and TNK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SS18L1	TNK1
Description		SS18L1 subunit of BAF chromatin remodeling complex	tyrosine kinase non receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Cytosol NBAF Complex	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Chromatin Organization Dendrite Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Dendrite Morphogenesis	Protein Phosphorylation Protein Autophosphorylation
Pathways		Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs			Fostamatinib
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		43 interacting genes: AATF ANKRD22 ATF3 ATN1 BAG4 BICRAL BRD1 C1orf94 CEP55 CREBBP CSTF2 DGCR6 ELF5 EP300 FAM168A GATAD1 HDAC2 HDAC4 HGS LGALS3 MAPK1IP1L MED30 MIA2 NAF1 NR1H3 PAX8 PCGF6 RFX6 RLIM SF3B4 SMAD1 SMAD3 SMARCA4 SNRPB SNRPC SSBP3 STAT3 TAF9B TCF7 TNK1 USP54 ZMIZ2 ZMYND19	8 interacting genes: FAM168A GRB10 PLCG1 SAXO1 SS18L1 UBC ZNF250 ZNF329
Entrez ID		26039	8711
HPRD ID		09398	09730
Ensembl ID		ENSG00000184402	ENSG00000174292
Uniprot IDs		B4DSR7 O75177	Q13470
PDB IDs			7T8J 7TCY 7TDY 7U4W 7U4Z 9CPL
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Transcription Cis-regulatory Region Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Chromatin DNA Binding Chromatin Remodeling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Transcription Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of MiRNA Transcription Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sterol Response Element Binding Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Organization SMAD Protein Signal Transduction Regulation Of Stem Cell Population Maintenance Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
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