TCEB2 and RNF7

Number of citations of the paper that reports this interaction (PMID 23333304)
16

Data Source:
BioGRID (pull down)

		TCEB2	RNF7
Gene Name		transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	ring finger protein 7
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome Elongin Complex	Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Cullin Family Protein Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Viral Process Protein Ubiquitination Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Protein Ubiquitination Negative Regulation Of Apoptotic Process Protein Neddylation Response To Redox State
Pathways		Vif-mediated degradation of APOBEC3G Formation of HIV-1 elongation complex containing HIV-1 Tat Cellular response to hypoxia RNA Polymerase II Transcription Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Elongation Class I MHC mediated antigen processing & presentation Host Interactions of HIV factors Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome Adaptive Immune System RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Hepatitis C induced liver fibrosis ( 22841784)
Protein-Protein Interactions		17 interactors: ASB2 ASB8 CEBPE CUL5 GNB2L1 LRRC41 PRAME RNF7 SOCS1 SOCS3 SOCS6 TCEB1 TCEB3 TCEB3B TCEB3C VHL ZYG11B	34 interactors: ASB2 CASP7 CBFB CDC34 CHFR CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS GEM GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L NFKBIA PLA2G15 TCEB1 TCEB2 TRIM46 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2M UBE2Q1
Entrez ID		6923	9616
HPRD ID		02874	04840
Ensembl ID		ENSG00000103363
Uniprot IDs		Q15370	Q9UBF6
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 3DCG 3ZKJ 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K	2ECL
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of JAK-STAT Cascade Protein Metabolic Process JAK-STAT Cascade Negative Regulation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Kinase Activity Cellular Metabolic Process Regulation Of JAK-STAT Cascade Regulation Of Growth Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Intracellular Signal Transduction Negative Regulation Of Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Metabolic Process Regulation Of Cellular Process Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Negative Regulation Of Cell Death Regulation Of Type I Interferon-mediated Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Viral Transcription Cellular Protein Catabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Signaling Response To Stress Transcription Elongation From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase Activity Cellular Response To Peptide Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Response To Insulin Stimulus	Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Viral Process Regulation Of DNA-templated Transcription In Response To Stress Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Protein Monoubiquitination Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Cycle Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Cell Cycle Apoptotic Signaling Pathway Apoptotic Process Cellular Response To Oxygen Levels Positive Regulation Of Metabolic Process Cellular Response To Stimulus Programmed Cell Death Cellular Metabolic Process Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Abiotic Stimulus Proteasomal Protein Catabolic Process Cell Cycle Arrest TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2	biologically bridges consistently cul degraded e3 etoposide hect ligase ligases list nedd4 proteasome rbx2 redox ring roc2 sag scf sensitizes shortened substrates terminus transcriptionally tri ubiquitin ubiquitylated ubiquitylates ubiquitylation
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteolytic psmd14 puma sequestosome top traf3 trp53bp2	biologically bridges consistently cul degraded e3 etoposide hect ligase ligases list nedd4 rbx2 redox ring roc2 sag scf sensitizes shortened substrates terminus transcriptionally tri ubiquitin ubiquitylated ubiquitylates ubiquitylation
Tagcloud (Intersection) ?		proteasome