TCEA1 and PAF1

Number of citations of the paper that reports this interaction (PubMedID 21596312)
52

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology)

		TCEA1	PAF1
Description		transcription elongation factor A1	PAF1 component of Paf1/RNA polymerase II complex
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		20 interacting genes: APP CDC73 CDK7 CEBPA CIRSR CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 SKIC8 SUPT6H UBR5	17 interacting genes: CEBPA ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3
Entrez ID		6917	54623
HPRD ID		03252	10140
Ensembl ID		ENSG00000187735	ENSG00000006712
Uniprot IDs		A0A384MTX4 B7Z4W0 P23193	Q8N7H5
PDB IDs		1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L 6ZUY 6ZV4 7CNF 7UNC 7UND 8A40 8UIS 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N	4M6T 5ZYQ 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation RNA Metabolic Process Cdc73/Paf1 Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Endodermal Cell Fate Commitment Nucleobase-containing Compound Biosynthetic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleus MRNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Metabolic Process Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Processing Wnt Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process RNA 3'-end Processing RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Complex Binding Negative Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation MRNA 3'-end Processing Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation	MSL Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Chromatin Binding Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation DNA Binding Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation Factor Complex Nucleolus NuA4 Histone Acetyltransferase Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Chromosome Protein Homodimerization Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Kinase C Signaling Histone H2B Ubiquitin Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Elongation Positive Regulation Of Gene Expression, Epigenetic Cerebellar Purkinje Cell Layer Maturation Response To Vitamin B2 C/EBP Complex
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