SLC41A1 and CLN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC41A1	CLN5
Description		solute carrier family 41 member 1	CLN5 lysosomal BMP synthase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Protein-containing Complex	Lysosome Lysosomal Membrane Vacuolar Lumen Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity Magnesium:sodium Antiporter Activity	Protein Binding D-mannose Binding Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Long-chain Fatty Acyl-CoA Hydrolase Activity Bis(monoacylglycero)phosphate Synthase Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Intracellular Magnesium Ion Homeostasis Magnesium Ion Transport Metal Ion Transport Sodium Ion Transmembrane Transport Cellular Response To Magnesium Ion Magnesium Ion Transmembrane Transport	Signal Peptide Processing Lysosome Organization Lysosomal Lumen Acidification Brain Development Visual Perception Neurogenesis Protein Catabolic Process Retrograde Transport, Endosome To Golgi Neuron Maturation Glycosylation Positive Regulation Of GTP Binding
Pathways		Metal ion SLC transporters
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Allergic sensitization ( 30013184) Atrial fibrillation ( 30061737) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Monocyte count ( 27863252 32888494) Parkinson's disease ( 28892059 21738487 19915576) Plateletcrit ( 32888494) Prostate cancer ( 25217961) Prostate-specific antigen levels ( 25434496 23269536) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 30072576) Major depressive disorder ( 34099189) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		32 interacting genes: AMIGO1 AQP6 AVPR2 CD79A CLN5 ELOVL7 ERGIC3 FAM209A FFAR2 FFAR3 GJA5 GJB5 GPR101 GPR152 GPR42 KASH5 LHFPL5 OPRM1 SLC10A1 SLC10A6 SLC13A4 SLC23A2 SSMEM1 SYNDIG1 SYPL2 TAAR9 TBXA2R TLCD4 TMEM237 TMEM248 TMEM31 TRHR	9 interacting genes: FDFT1 GPR152 IGF2 INS-IGF2 OGT PLPP6 SLC41A1 SLC41A2 TMEM31
Entrez ID		254428	1203
HPRD ID		15388	07619
Ensembl ID		ENSG00000133065	ENSG00000102805
Uniprot IDs		B2RMP2 Q8IVJ1	A0A1B0GTR6 O75503
PDB IDs			6R99
Enriched GO Terms of Interacting Partners?		Membrane G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Positive Regulation Of Vasoconstriction Bile Acid:sodium Symporter Activity Symporter Activity Renal Water Transport Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Blood Pressure Sodium Ion Transport Protein Binding Connexin Complex Nitrate Transmembrane Transporter Activity Transmembrane Transport Water Transport Renal System Process System Process Renal Water Retention Positive Regulation Of Blood Pressure Bis(monoacylglycero)phosphate Synthase Activity Positive Regulation Of GTP Binding Vacuolar Lumen Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Metal Ion Transport Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Positive Regulation Of Acute Inflammatory Response Mucosal Immune Response Organ Or Tissue Specific Immune Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Ethanol Bile Acid And Bile Salt Transport	Farnesyl Diphosphate Metabolic Process Inorganic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Insulin Receptor Binding Cholesterol Biosynthetic Process Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Terpenoid Metabolic Process Steroid Biosynthetic Process Nickel Cation Transport Magnesium:sodium Antiporter Activity Regulation Of Glucose Metabolic Process Isoprenoid Metabolic Process Cholesterol Metabolic Process Hormone Activity Protein O-acetylglucosaminyltransferase Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Sterol Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Embryonic Placenta Morphogenesis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Intracellular Magnesium Ion Homeostasis Cellular Response To Magnesium Ion Lipid Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity Regulation Of Skeletal Muscle Tissue Growth Carbon Catabolite Regulation Of Transcription Lysophosphatidic Acid Phosphatase Activity Cobalt Ion Transport Regulation Of Transcription By Glucose Protein Prenylation Exocrine Pancreas Development NSL Complex Regulation Of Neutrophil Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?