CCDC88C and TSC22D1

		CCDC88C	TSC22D1
Description		coiled-coil and HOOK domain protein 88C	TSC22 domain family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cell Junction Apical Junction Complex Anchoring Junction	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Frizzled Binding Protein Binding Microtubule Binding PDZ Domain Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding	Transcription Coactivator Activity Protein Binding Identical Protein Binding
	Biological Process	Microtubule Bundle Formation Cilium Movement Apical Constriction Negative Regulation Of Microtubule Depolymerization Signal Transduction Small GTPase-mediated Signal Transduction Wnt Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Protein Destabilization Non-canonical Wnt Signaling Pathway Cilium Organization Positive Regulation Of JNK Cascade Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Mucociliary Clearance Respiratory Basal Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Daytime sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		9 interacting genes: APP DVL1 FBXO7 FZD6 FZD7 GNAI3 ITSN2 MAPK8 MPDZ	51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1
Entrez ID		440193	8848
HPRD ID		19136	07414
Ensembl ID		ENSG00000015133	ENSG00000102804
Uniprot IDs		B4DZB8 Q9P219	A8K3Y6 Q15714
PDB IDs
Enriched GO Terms of Interacting Partners?		Frizzled Binding Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Catabolic Process Canonical Wnt Signaling Pathway Collateral Sprouting Wnt Receptor Activity Neuronal Dense Core Vesicle Protein Serine/threonine Kinase Binding Apicolateral Plasma Membrane Wnt-protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Macroautophagy Neuron Projection Organization Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Activation Modulation Of Excitatory Postsynaptic Potential Wnt Signaling Pathway JUN Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Neuron Projection Regulation Of Purine Nucleotide Metabolic Process G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization To Presynapse Positive Regulation Of Cardiolipin Metabolic Process Clathrin-dependent Synaptic Vesicle Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
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