TAPBP

Description		TAP binding protein
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Tapasin-ERp57 Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class I Protein Complex Binding MHC Class I Protein Binding Peptide Antigen Binding Protein Folding Chaperone TAP1 Binding TAP2 Binding Unfolded Protein Binding Molecular Adaptor Activity TAP Complex Binding
	Biological Process	MHC Class Ib Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Assembly With MHC Class I Protein Complex Protein Folding Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Regulation Of Gene Expression Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Antigen Stabilization Regulation Of Protein Complex Stability Protein-containing Complex Assembly
Pathways		ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases		Bare lymphocyte syndrome (BLS) type1
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576)
Novel Interacting Genes		1 novel interacting genes: TNF
Interacting Genes		9 interacting genes: CALR COPB1 COPG1 COPG2 HLA-A HLA-C TAP1 TAP2 UBC
Entrez ID		6892
HPRD ID		09061
Ensembl ID		ENSG00000231925
Uniprot IDs		A0A024RCT1 A0A0A0MSV9 A0A0A0MT98 A0A8V8TQC5 O15533
PDB IDs		3F8U 6ENY 7QNG 7QPD 7TUE 7TUF 7TUG
Enriched GO Terms of Interacting Partners?		MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen COPI Vesicle Coat Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib COPI-coated Vesicle Membrane Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex Membrane Coat Lumenal Side Of Endoplasmic Reticulum Membrane Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Intra-Golgi Vesicle-mediated Transport Positive Regulation Of T Cell Mediated Cytotoxicity TAP Binding ABC-type Peptide Transporter Activity TAP1 Binding Regulation Of T Cell Mediated Cytotoxicity Cytosol To Endoplasmic Reticulum Transport Regulation Of Lymphocyte Mediated Immunity Endoplasmic Reticulum Cellular Localization Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains MHC Class Ib Protein Binding Regulation Of Adaptive Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity MHC Protein Binding Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Protein Transport Intracellular Protein Localization MHC Class I Protein Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Positive Regulation Of Immune Effector Process Golgi Membrane Intracellular Transport Adaptive Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
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