CCDC134 and PTPRN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC134	PTPRN
Description		coiled-coil domain containing 134	protein tyrosine phosphatase receptor type N
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Membrane	Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Secretory Granule Axon Transport Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuronal Cell Body Perikaryon Axon Terminus Synapse
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Angiogenesis Placenta Development Ventricular System Development Positive Regulation Of Wnt Signaling Pathway Regulation Of Ossification Positive Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Embryonic Hemopoiesis Regulation Of Protein Glycosylation Embryonic Liver Development	Response To Reactive Oxygen Species Luteinization Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease biomarkers ( 21123754) Intelligence (MTAG) ( 29326435) Meat-related diet ( 32066663) Plateletcrit ( 32888494) Processed meat consumption ( 32066663) Refractive error ( 32231278)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean reticulocyte volume ( 32888494)
Interacting Genes		4 interacting genes: PGRMC1 PTPRN TADA2A UBQLN4	19 interacting genes: CAPN2 CCDC134 CLN8 GJA8 GPR152 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 TIMMDC1 TMEM80 TRDN UBQLN4
Entrez ID		79879	5798
HPRD ID		07988	03466
Ensembl ID		ENSG00000100147	ENSG00000054356
Uniprot IDs		B0QY51 B4DRL0 Q9H6E4	Q16849 Q96IA0
PDB IDs			2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?		Dense Core Granule Maturation Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Chromosome SAGA-type Complex Positive Regulation Of Lipoprotein Transport Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex	Membrane Structural Constituent Of Myelin Sheath Central Nervous System Myelination
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