TAC1 and SGCE

Data Source: HiPPIP (Novel)

		TAC1	SGCE
Name		tachykinin precursor 1	sarcoglycan epsilon
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Neuronal Cell Body Synapse Neuronal Dense Core Vesicle	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Membrane Dendrite Dendrite Membrane Sarcolemma Cell Projection
	Molecular Function	Protein Binding Substance P Receptor Binding Neuromedin K Receptor Binding Substance K Receptor Binding Receptor Ligand Activity	None
	Biological Process	Response To Yeast Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Innate Immune Response Positive Regulation Of Action Potential Positive Regulation Of Ossification Response To Pain Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Stress Fiber Assembly Regulation Of Sensory Perception Of Pain Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Sensory Perception Of Pain Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion	Cell-matrix Adhesion Muscle Organ Development
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Adventurousness ( 30643258 ) Adverse response to radiation therapy ( 23719583 ) Blood protein levels ( 30072576 ) Feeling nervous ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Regular attendance at a religious group ( 29970889 ) Response to platinum-based agents ( 22020760 ) Squamous cell lung carcinoma ( 28604730 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: CDK6 SGCE	10 novel interactors: AKAP9 CDK14 CDK6 CYP3A7 MED12 MTERF1 PDYN SEMA3C SYT13 TAC1
Interacting Genes		10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6	4 interacting genes: ARIH2 CWC15 KEAP1 PPP1CC
Entrez ID		6863	8910
HPRD ID		08876	04999
Ensembl ID		ENSG00000006128	ENSG00000127990
Uniprot IDs		P20366 Q9Y494	A0A0S2Z4P5 A0A2R8Y448 A0A2R8Y5J3 A0A2R8YGQ3 B4DP78 C9JR67 E9PEH6 O43556
PDB IDs		2B19 2KS9 2KSA 2KSB 4HOM 7P00 7P02 7RMG 7RMH 7VDM 7XWO 8JBH 8U26	Not available
GO Terms Enriched among Interactors		Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Sperm Head Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Membrane Cyclin Binding Regulation Of Reproductive Process Response To Electrical Stimulus Peptide Hormone Processing Regulation Of Hormone Levels Signaling Receptor Ligand Precursor Processing Regulation Of Cell Motility Regulation Of Vascular Permeability Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Regulation Of Biological Quality Smooth Muscle Contraction Regulation Of Microtubule-based Process Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Maturation Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Angiotensin-mediated Drinking Behavior Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Regulation Of Multicellular Organismal Process	None