ABCC8 and KCNJ11

Number of citations: 0 (PubMedID 12941953)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		ABCC8	KCNJ11
Name		ATP binding cassette subfamily C member 8	potassium inwardly rectifying channel subfamily J member 11
Structure
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma Presynaptic Membrane	Cytoplasm Plasma Membrane Inward Rectifying Potassium Channel Membrane T-tubule Protein-containing Complex Monoatomic Ion Channel Complex
	Molecular Function	Nucleotide Binding Potassium Channel Activity Protein Binding ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding ABC-type Transporter Activity	Nucleotide Binding Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Action Potential Intracellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Cellular Response To Nutrient Levels Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Potassium Ion Transport Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Neuromuscular Process Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Glutamate Secretion, Neurotransmission Negative Regulation Of Neuroblast Migration Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability Potassium Ion Import Across Plasma Membrane	Action Potential Response To Hypoxia Response To Ischemia Ventricular Cardiac Muscle Tissue Development Glucose Metabolic Process Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Determination Of Adult Lifespan Response To Xenobiotic Stimulus Cellular Response To Nutrient Levels Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process CAMKK-AMPK Signaling Cascade Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Presynaptic Membrane Potential Response To Resveratrol Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine	Glimepiride Ibutilide Verapamil Tolazamide Ritodrine Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)	Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM) Type II diabetes mellitus
GWAS		Academic attainment (English) ( 33594131 ) Alcohol dependence symptom count ( 29460428 ) Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 ) Circulating leptin levels or type 2 diabetes ( 32341051 ) Gout ( 22179738 ) Mean arterial pressure ( 27618448 ) Metabolite levels ( 23823483 ) Two-hour glucose ( 34059833 ) Type 2 diabetes ( 29632382 32499647 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Weight ( 34074324 )	Body mass index ( 29273807 28892062 25673413 26426971 ) Circulating leptin levels or type 2 diabetes ( 32341051 ) Mean arterial pressure ( 27618448 ) Medication use (drugs used in diabetes) ( 31015401 ) Pulse pressure ( 30578418 27618448 ) Social communication problems ( 24564958 ) Systolic blood pressure ( 30578418 27618448 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Type 2 diabetes ( 30718926 31118516 17463246 30297969 30054458 32499647 29632382 29358691 28869590 24509480 22885922 19056611 18372903 17463249 17463248 ) Type 2 diabetes (adjusted for BMI) ( 29632382 )
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA
Entrez ID		6833	3767
HPRD ID		02741	09022
Ensembl ID		ENSG00000006071	ENSG00000187486
Uniprot IDs		A0A2R8Y4V0 A0A2R8Y5D8 A0A2R8YDG0 Q09428	A0A804HHV7 B2RC52 Q14654
PDB IDs		6C3O 6C3P 7S5V 7S5X 7S5Y 7S5Z 7S60 7S61	6C3O 6C3P 7S5T 7S5X 7S5Y 7S5Z 7S60 7S61
GO Terms Enriched among Interactors		Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Regulation Of Hormone Secretion Regulation Of Protein Secretion Response To ATP Determination Of Adult Lifespan Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Potassium Ion Import Across Plasma Membrane Vasodilation Response To Ischemia Cardiac Muscle Tissue Development Regulation Of Protein Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion System Process Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Atrioventricular Node Cell Differentiation Inorganic Cation Import Across Plasma Membrane Regulation Of Transport Regulation Of Secretion By Cell Action Potential Regulation Of Secretion Proteinase-activated Receptor Activity Negative Regulation Of Protein Transport Myeloid Leukocyte Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Striated Muscle Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Negative Regulation Of Establishment Of Protein Localization	Potassium Ion-transporting ATPase Complex Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Glutamate Secretion, Neurotransmission Import Into Cell Regulation Of Potassium Ion Transport Sarcolemma Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Glutamate Secretion Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Circulatory System Development Membrane Repolarization During Action Potential Inward Rectifier Potassium Channel Activity Regulation Of System Process Metal Ion Transport Coronary Vasculature Development Regulation Of Heart Contraction Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization Response To ATP L-glutamate Import Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Neurotransmitter Secretion Fibroblast Proliferation ABC-type Transporter Activity Vascular Process In Circulatory System Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Acidic Amino Acid Transport Vasodilation Heart Morphogenesis Circulatory System Process Monoatomic Ion Transport