ABCC8 and KCNJ11

Number of citations of the paper that reports this interaction (PMID 7502040)
300

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ABCC8	KCNJ11
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 8	potassium channel, inwardly rectifying subfamily J, member 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex	Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber
	Molecular Function	ATP Binding Sulfonylurea Receptor Activity Potassium Ion Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding	Voltage-gated Potassium Channel Activity ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding
	Biological Process	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Potassium Ion Transport Signal Transduction Synaptic Transmission Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport	Response To Ischemia Glucose Metabolic Process Energy Reserve Metabolic Process Synaptic Transmission Potassium Ion Import Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Neurological System Process Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Positive Regulation Of Cation Channel Activity
Pathways		Inwardly rectifying K+ channels ABC-family proteins mediated transport Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels	Inwardly rectifying K+ channels Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels
Drugs		Adenosine triphosphate Glimepiride Chlorpropamide Nateglinide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glycodiazine	Glimepiride Ibutilide Verapamil Levosimendan Glyburide Diazoxide Thiamylal
Diseases
GWAS			Type 2 diabetes ( 18372903 17463246 17463248 17463249 19056611)
Protein-Protein Interactions		4 interactors: CRYBB1 ENSA KCNJ11 KCNJ8	6 interactors: ABCC8 ABCC9 AP2M1 KCNJ2 KCNJ8 LDHA
Entrez ID		6833	3767
HPRD ID		02741	09022
Ensembl ID		ENSG00000006071	ENSG00000187486
Uniprot IDs		Q09428	B2RC52 Q14654
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Response To Glucose Potassium Ion Transmembrane Transport Response To Carbohydrate Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Cellular Response To Nicotine Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Protein Transport Regulation Of Secretion Response To ATP Response To Organic Substance Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Cation Channel Activity Vasodilation Response To Ischemia Response To PH Response To Testosterone Regulation Of Protein Localization Response To Nicotine Cellular Response To Alkaloid Negative Regulation Of Insulin Secretion Metal Ion Transport Response To Lipid Negative Regulation Of Peptide Secretion Response To Organic Cyclic Compound Response To Exogenous DsRNA Cell-cell Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Cation Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Glucose Stimulus Regulation Of Cellular Localization Negative Regulation Of Hormone Secretion Response To DsRNA Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Glucose Homeostasis Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Cellular Response To Carbohydrate Stimulus Neurological System Process Cation Transport Negative Regulation Of Protein Secretion	Potassium Ion Import Potassium Ion Transmembrane Transport Synaptic Transmission Potassium Ion Transport Cell-cell Signaling Monovalent Inorganic Cation Transport Response To External Stimulus Metal Ion Transport Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Cell Communication Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Transmembrane Transport Ion Transport Relaxation Of Skeletal Muscle Defense Response To Virus Response To Stimulus Response To Virus Regulation Of Resting Membrane Potential Transport Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Signaling Generation Of Precursor Metabolites And Energy Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Negative Regulation Of Protein Localization To Plasma Membrane Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Magnesium Ion Transport Regulation Of Defense Response To Virus By Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cellular Response To Stimulus Vasodilation Membrane Depolarization During Action Potential Response To PH Cardiac Muscle Cell Action Potential Clathrin-mediated Endocytosis Substantia Nigra Development Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport
Tagcloud ?		2kd antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis pcsk2 peg3 producing proglucagon protected recognize reserved rights scg2 specificities	5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1
Tagcloud (Difference) ?		2kd antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis pcsk2 peg3 producing proglucagon protected recognize reserved rights scg2 specificities	5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1
Tagcloud (Intersection) ?