ABCC8 and ENSA

Number of citations of the paper that reports this interaction (PubMedID 9653196)
28

Data Source:
HPRD (in vivo)

		ABCC8	ENSA
Description		ATP binding cassette subfamily C member 8	endosulfine alpha
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma Presynaptic Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Potassium Channel Activity Protein Binding ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding ABC-type Transporter Activity	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Phosphatase Inhibitor Activity Potassium Channel Inhibitor Activity Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Action Potential Intracellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Cellular Response To Nutrient Levels Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Potassium Ion Transport Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Neuromuscular Process Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Glutamate Secretion, Neurotransmission Negative Regulation Of Neuroblast Migration Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability Potassium Ion Import Across Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Nutrient Regulation Of Insulin Secretion Cell Division
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Academic attainment (English) ( 33594131) Alcohol dependence symptom count ( 29460428) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Two-hour glucose ( 34059833) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 34074324)	Albumin-globulin ratio ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Mean corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Morning person ( 30696823) Neutrophil percentage of granulocytes ( 27863252) Non-albumin protein levels ( 29403010) Pericardial adipose tissue adjusted for height and weight ( 27918534) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	11 interacting genes: ABCC8 ACD ARIH2 DNMT1 ENO2 KCTD15 POT1 PSEN1 RAP2A SNCA SRPK2
Entrez ID		6833	2029
HPRD ID		02741	11927
Ensembl ID		ENSG00000006071	ENSG00000143420
Uniprot IDs		A0A2R8Y4V0 A0A2R8Y5D8 A0A2R8YDG0 Q09428	O43768
PDB IDs		6C3O 6C3P 7S5V 7S5X 7S5Y 7S5Z 7S60 7S61
Enriched GO Terms of Interacting Partners?		Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Regulation Of Hormone Secretion Regulation Of Protein Secretion Response To ATP Determination Of Adult Lifespan Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Potassium Ion Import Across Plasma Membrane Vasodilation Response To Ischemia Cardiac Muscle Tissue Development Regulation Of Protein Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion System Process Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Atrioventricular Node Cell Differentiation Inorganic Cation Import Across Plasma Membrane Regulation Of Transport Regulation Of Secretion By Cell Action Potential Regulation Of Secretion Proteinase-activated Receptor Activity Negative Regulation Of Protein Transport Myeloid Leukocyte Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Striated Muscle Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Negative Regulation Of Establishment Of Protein Localization	Magnesium Ion Binding Synaptic Membrane Telomerase Inhibitor Activity Shelterin Complex Telomere Assembly Establishment Of Protein Localization To Telomere Nuclear Telomere Cap Complex Telomere Capping Positive Regulation Of Receptor Recycling Positive Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization Growth Cone Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Receptor Recycling RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cell Cortex L-glutamate Import Regulation Of Protein Localization Nuclear Outer Membrane Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Neurotransmitter Secretion Regulation Of Establishment Of Protein Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Acidic Amino Acid Transport Regulation Of Neuron Apoptotic Process Organelle Organization Segmentation Negative Regulation Of Core Promoter Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Cell Development Regulation Of Dendrite Morphogenesis
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