ABCC8 and KCNJ8

Number of citations: 0 (PubMedID 11160857)
Data Source: HPRD (in vitro)

		ABCC8	KCNJ8
Name		ATP binding cassette subfamily C member 8	potassium inwardly rectifying channel subfamily J member 8
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma Presynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Membrane Myofibril Potassium Ion-transporting ATPase Complex Protein-containing Complex Monoatomic Ion Channel Complex Sarcolemma Presynaptic Active Zone Membrane Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Potassium Channel Activity Protein Binding ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding ABC-type Transporter Activity	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Action Potential Intracellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Cellular Response To Nutrient Levels Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Potassium Ion Transport Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Neuromuscular Process Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Glutamate Secretion, Neurotransmission Negative Regulation Of Neuroblast Migration Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability Potassium Ion Import Across Plasma Membrane	Action Potential Blood Vessel Development Response To Hypoxia Microglial Cell Activation Kidney Development Vasculature Development Regulation Of Heart Rate Adaptive Immune Response Response To Ischemia Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Inflammatory Response Heart Development Regulation Of Blood Pressure Cell Population Proliferation Determination Of Adult Lifespan Protein Secretion Response To Xenobiotic Stimulus Gene Expression Fatty Acid Transport Transmission Of Nerve Impulse Establishment Of Cell Polarity Response To Lipopolysaccharide Response To Insulin Response To ATP Response To Cytokine Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress P38MAPK Cascade Vasodilation Response To Exogenous DsRNA NLRP3 Inflammasome Complex Assembly Fat Cell Differentiation Fibroblast Proliferation Nervous System Process Neuromuscular Process Synaptic Assembly At Neuromuscular Junction Defense Response To Virus Cardiac Pacemaker Cell Differentiation Atrioventricular Node Cell Differentiation Coronary Vasculature Development Glutamate Secretion, Neurotransmission CAMKK-AMPK Signaling Cascade Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Circulatory System Development Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Membrane Potential Reactive Gliosis Transport Across Blood-brain Barrier Response To Resveratrol Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine	Ritodrine Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)	None
GWAS		Academic attainment (English) ( 33594131 ) Alcohol dependence symptom count ( 29460428 ) Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 ) Circulating leptin levels or type 2 diabetes ( 32341051 ) Gout ( 22179738 ) Mean arterial pressure ( 27618448 ) Metabolite levels ( 23823483 ) Two-hour glucose ( 34059833 ) Type 2 diabetes ( 29632382 32499647 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Weight ( 34074324 )	Birth weight ( 31043758 )
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54
Entrez ID		6833	3764
HPRD ID		02741	02962
Ensembl ID		ENSG00000006071	ENSG00000121361
Uniprot IDs		A0A2R8Y4V0 A0A2R8Y5D8 A0A2R8YDG0 Q09428	Q15842
PDB IDs		6C3O 6C3P 7S5V 7S5X 7S5Y 7S5Z 7S60 7S61	Not available
GO Terms Enriched among Interactors		Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Regulation Of Hormone Secretion Regulation Of Protein Secretion Response To ATP Determination Of Adult Lifespan Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Potassium Ion Import Across Plasma Membrane Vasodilation Response To Ischemia Cardiac Muscle Tissue Development Regulation Of Protein Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion System Process Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Atrioventricular Node Cell Differentiation Inorganic Cation Import Across Plasma Membrane Regulation Of Transport Regulation Of Secretion By Cell Action Potential Regulation Of Secretion Proteinase-activated Receptor Activity Negative Regulation Of Protein Transport Myeloid Leukocyte Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Striated Muscle Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Negative Regulation Of Establishment Of Protein Localization	Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion-transporting ATPase Complex Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Transmembrane Transporter Binding Inward Rectifier Potassium Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To ATP System Process Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Insulin Secretion ABC-type Transporter Activity T-tubule Negative Regulation Of Peptide Secretion Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Monoatomic Ion Transport Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Hormone Secretion TMEM240-body Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Negative Regulation Of Protein Secretion Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Potassium Channel Activity Regulation Of Protein Transport Transmembrane Transport Relaxation Of Skeletal Muscle Sarcolemma Regulation Of Establishment Of Protein Localization Regulation Of System Process