ABCC8 and KCNJ8

Number of citations of the paper that reports this interaction (PMID 11160857)
24

Data Source:
HPRD (in vitro)

		ABCC8	KCNJ8
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 8	potassium channel, inwardly rectifying subfamily J, member 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Myofibril Sarcolemma
	Molecular Function	ATP Binding Sulfonylurea Receptor Activity Potassium Ion Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding
	Biological Process	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Potassium Ion Transport Signal Transduction Synaptic Transmission Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport	Kidney Development Potassium Ion Transport Synaptic Transmission Heart Development Response To PH Potassium Ion Import Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Vasodilation Response To Exogenous DsRNA Defense Response To Virus
Pathways		Inwardly rectifying K+ channels ABC-family proteins mediated transport Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels	Inwardly rectifying K+ channels ATP sensitive Potassium channels Potassium Channels
Drugs		Adenosine triphosphate Glimepiride Chlorpropamide Nateglinide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glycodiazine
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CRYBB1 ENSA KCNJ11 KCNJ8	4 interactors: ABCC8 ABCC9 KCNJ11 KCNJ2
Entrez ID		6833	3764
HPRD ID		02741	02962
Ensembl ID		ENSG00000006071	ENSG00000121361
Uniprot IDs		Q09428	Q15842
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Response To Glucose Potassium Ion Transmembrane Transport Response To Carbohydrate Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Cellular Response To Nicotine Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Protein Transport Regulation Of Secretion Response To ATP Response To Organic Substance Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Cation Channel Activity Vasodilation Response To Ischemia Response To PH Response To Testosterone Regulation Of Protein Localization Response To Nicotine Cellular Response To Alkaloid Negative Regulation Of Insulin Secretion Metal Ion Transport Response To Lipid Negative Regulation Of Peptide Secretion Response To Organic Cyclic Compound Response To Exogenous DsRNA Cell-cell Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Cation Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Glucose Stimulus Regulation Of Cellular Localization Negative Regulation Of Hormone Secretion Response To DsRNA Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Glucose Homeostasis Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Cellular Response To Carbohydrate Stimulus Neurological System Process Cation Transport Negative Regulation Of Protein Secretion	Potassium Ion Import Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Monovalent Inorganic Cation Transport Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Transmembrane Transport Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Energy Reserve Metabolic Process Relaxation Of Skeletal Muscle Positive Regulation Of Ion Transport Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Regulation Of Membrane Potential Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Nicotine Regulation Of Resting Membrane Potential Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Regulation Of Protein Secretion Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Generation Of Precursor Metabolites And Energy Regulation Of Ion Transmembrane Transport Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Chemical Homeostasis Signaling Cell Communication Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transport Regulation Of Protein Transport Magnesium Ion Transport Regulation Of Secretion Response To ATP Regulation Of Establishment Of Protein Localization Cardiac Muscle Cell Action Potential Involved In Contraction
Tagcloud ?		2kd antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis pcsk2 peg3 producing proglucagon protected recognize reserved rights scg2 specificities	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Difference) ?		2kd antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis pcsk2 peg3 producing proglucagon protected recognize reserved rights scg2 specificities	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Intersection) ?