ABCC8

Name	ATP binding cassette subfamily C member 8
Structure
Interactors	5 interactors: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma Presynaptic Membrane
	Molecular Function	Nucleotide Binding Potassium Channel Activity Protein Binding ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding ABC-type Transporter Activity
	Biological Process	Action Potential Intracellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Cellular Response To Nutrient Levels Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Potassium Ion Transport Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Neuromuscular Process Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Glutamate Secretion, Neurotransmission Negative Regulation Of Neuroblast Migration Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability Potassium Ion Import Across Plasma Membrane
Pathways	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs	ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases	Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS	Academic attainment (English) ( 33594131 ) Alcohol dependence symptom count ( 29460428 ) Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 ) Circulating leptin levels or type 2 diabetes ( 32341051 ) Gout ( 22179738 ) Mean arterial pressure ( 27618448 ) Metabolite levels ( 23823483 ) Two-hour glucose ( 34059833 ) Type 2 diabetes ( 29632382 32499647 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Weight ( 34074324 )
Entrez ID	6833
HPRD ID	02741
Ensembl ID	ENSG00000006071
Uniprot IDs	A0A2R8Y4V0 A0A2R8Y5D8 A0A2R8YDG0 Q09428
PDB IDs	6C3O 6C3P 7S5V 7S5X 7S5Y 7S5Z 7S60 7S61
GO Terms Enriched among Interactors ?	Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Regulation Of Hormone Secretion Regulation Of Protein Secretion Response To ATP Determination Of Adult Lifespan Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Potassium Ion Import Across Plasma Membrane Vasodilation Response To Ischemia Cardiac Muscle Tissue Development Regulation Of Protein Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion System Process Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Atrioventricular Node Cell Differentiation Inorganic Cation Import Across Plasma Membrane Regulation Of Transport Regulation Of Secretion By Cell Action Potential Regulation Of Secretion Proteinase-activated Receptor Activity Negative Regulation Of Protein Transport Myeloid Leukocyte Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Striated Muscle Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Negative Regulation Of Establishment Of Protein Localization