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SULT1C2 and RASGRP3
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
SULT1C2
RASGRP3
Gene Name
sulfotransferase family, cytosolic, 1C, member 2
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Vesicular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
Guanyl-nucleotide Exchange Factor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Sulfotransferase Activity
Signal Transducer Activity
Guanyl-nucleotide Exchange Factor Activity
Ras Guanyl-nucleotide Exchange Factor Activity
Calcium Ion Binding
Ras GTPase Binding
Kinase Binding
Diacylglycerol Binding
Rap GTPase Activator Activity
Biological Process
Xenobiotic Metabolic Process
Amine Metabolic Process
Small Molecule Metabolic Process
3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Sulfation
MAPK Cascade
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Positive Regulation Of Rap GTPase Activity
Positive Regulation Of GTPase Activity
Pathways
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Defective UGT1A4 causes hyperbilirubinemia
Metabolic disorders of biological oxidation enzymes
Phase II conjugation
Defective UGT1A1 causes hyperbilirubinemia
Cytosolic sulfonation of small molecules
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Biological oxidations
Defective GGT1 causes Glutathionuria (GLUTH)
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Signaling by the B Cell Receptor (BCR)
Downstream signaling events of B Cell Receptor (BCR)
Activation of RAS in B cells
Adaptive Immune System
Drugs
Diseases
GWAS
Hypertension (young onset) (
19421330
)
Systemic lupus erythematosus (
23273568
19838193
)
Protein-Protein Interactions
6 interactors:
ACD
HLTF
POT1
RASGRP3
TERF1
TINF2
9 interactors:
APP
DYNLL2
PIK3CA
PRKACA
PRKCB
PRKCD
PRKCE
PRKCQ
SULT1C2
Entrez ID
6819
25780
HPRD ID
03858
15213
Ensembl ID
ENSG00000198203
ENSG00000152689
Uniprot IDs
B4DLP0
O00338
Q8IV61
PDB IDs
3BFX
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance
Telomere Assembly
Negative Regulation Of DNA Replication
Telomere Maintenance
Negative Regulation Of Chromosome Organization
Regulation Of Telomerase Activity
Negative Regulation Of DNA Metabolic Process
Regulation Of DNA Replication
Telomere Maintenance Via Telomere Lengthening
Regulation Of Chromosome Organization
Regulation Of DNA Biosynthetic Process
Telomere Capping
Protein Localization To Chromosome, Telomeric Region
Chromosome Organization
Positive Regulation Of Telomerase Activity
DNA Metabolic Process
Negative Regulation Of Telomerase Activity
Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
RNA-dependent DNA Replication
Negative Regulation Of DNA Biosynthetic Process
Protein Localization To Chromosome
Regulation Of Organelle Organization
Positive Regulation Of Organelle Organization
Positive Regulation Of DNA Replication
Negative Regulation Of Biosynthetic Process
Homeostatic Process
Organelle Organization
Negative Regulation Of Protein ADP-ribosylation
Positive Regulation Of Single-stranded Telomeric DNA Binding
Positive Regulation Of DNA Strand Elongation
Regulation Of Protein ADP-ribosylation
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Cellular Component Assembly
Regulation Of Cellular Component Organization
Telomeric Loop Formation
Telomere Formation Via Telomerase
Age-dependent Telomere Shortening
Negative Regulation Of Cellular Metabolic Process
Telomere Maintenance Via Telomere Shortening
Negative Regulation Of Protein Glycosylation
Regulation Of Metabolic Process
Protection From Non-homologous End Joining At Telomere
Regulation Of Catalytic Activity
Nucleobase-containing Compound Metabolic Process
Platelet Activation
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Negative Regulation Of Insulin Receptor Signaling Pathway
Response To Wounding
Regulation Of Insulin Receptor Signaling Pathway
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Platelet Aggregation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Immune System Process
Protein Phosphorylation
Regulation Of Wound Healing
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Histone H3-T6 Phosphorylation
Regulation Of Platelet Activation
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Immune System Process
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Immune Response-regulating Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Cellular Ketone Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Peptidyl-threonine Phosphorylation
Phosphorylation
Intracellular Signal Transduction
Regulation Of Peptidyl-tyrosine Phosphorylation
Activation Of Phospholipase C Activity
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Phospholipase C Activity
Regulation Of Cell Adhesion
Positive Regulation Of Immune Response
Immune Response
Fc Receptor Signaling Pathway
Regulation Of Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Defense Response
Positive Regulation Of Phospholipase Activity
Tagcloud
?
activating
arthritis
cas9
colitis
coupling
crispr
destruct
dextrane
editing
elucidated
excessive
gtpases
guanine
impairs
invading
limits
nucleotide
rap
rap1
raw264
releasing
relieves
sulphate
switches
threshold
tlr
tlr3
toll
Tagcloud (Difference)
?
activating
arthritis
cas9
colitis
coupling
crispr
destruct
dextrane
editing
elucidated
excessive
gtpases
guanine
impairs
invading
limits
nucleotide
rap
rap1
raw264
releasing
relieves
sulphate
switches
threshold
tlr
tlr3
toll
Tagcloud (Intersection)
?