SULT1C2

Gene Name		sulfotransferase family, cytosolic, 1C, member 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Sulfotransferase Activity
	Biological Process	Xenobiotic Metabolic Process Amine Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: ACD HLTF POT1 RASGRP3 TERF1 TINF2
Entrez ID		6819
HPRD ID		03858
Ensembl ID		ENSG00000198203
Uniprot IDs		B4DLP0 O00338
PDB IDs		3BFX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Chromosome Organization Positive Regulation Of Telomerase Activity DNA Metabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Positive Regulation Of DNA Replication Negative Regulation Of Biosynthetic Process Homeostatic Process Organelle Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Regulation Of Protein ADP-ribosylation Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cellular Component Assembly Regulation Of Cellular Component Organization Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Metabolic Process Protection From Non-homologous End Joining At Telomere Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process
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