STX3 and VAMP8

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		STX3	VAMP8
Description		syntaxin 3	vesicle associated membrane protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Vacuole Plasma Membrane Cell-cell Junction Endomembrane System Membrane Apical Plasma Membrane Lamellipodium Secretory Granule Dendrite Growth Cone SNARE Complex Melanosome Specific Granule Azurophil Granule Zymogen Granule Membrane Neuron Projection Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Plasma Membrane Bounded Cell Projection	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Plasma Membrane Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Zymogen Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Mucin Granule
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Arachidonate Binding	SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding
	Biological Process	Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Cell Adhesion Vesicle Docking Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Fusion Organelle Membrane Fusion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Vesicle Fusion Autophagy Protein Transport Vesicle-mediated Transport Autophagosome Membrane Docking SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Protein-containing Complex Organization Symbiont Entry Into Host Cell Defense Response To Virus Mucus Secretion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell
Pathways		Other interleukin signaling	ER-Phagosome pathway trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183)	Coronary artery disease ( 26343387 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		54 interacting genes: AQP6 CD79A COQ9 CPLX2 CPLX4 CREB3L1 CYB561 DNAJC5 EBAG9 ELOVL4 ERGIC3 EVI5 FAM209A FXYD3 GPR152 GPX8 JAGN1 LMNA MANBAL MGST3 MMGT1 MSMO1 MTIF3 NAPB PGRMC2 REEP4 RMDN3 SCN3B SLC10A6 SLC35H1 SLC71A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STX5 STXBP1 STXBP2 SYT1 SYT4 SYT7 TBC1D30 TMEM14B TMPPE TMX2 TRPC3 TXLNA UBC VAMP3 VAMP7 VAMP8 ZDHHC15	11 interacting genes: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2
Entrez ID		6809	8673
HPRD ID		15985	04415
Ensembl ID		ENSG00000166900	ENSG00000118640
Uniprot IDs		A0A286YF28 Q13277 Q53YE2	B8ZZT4 Q9BV40
PDB IDs			4WY4 7BV6
Enriched GO Terms of Interacting Partners?		Exocytosis SNARE Complex Secretion By Cell SNARE Binding Vesicle Fusion Syntaxin Binding Organelle Membrane Fusion Organelle Localization By Membrane Tethering SNAP Receptor Activity Secretion Membrane Docking Organelle Fusion Regulated Exocytosis Synaptic Vesicle Exocytosis Membrane Fusion Vesicle Docking Vesicle Organization Membrane Signal Release Calcium-ion Regulated Exocytosis Vesicle-mediated Transport Positive Regulation Of Regulated Secretory Pathway Vesicle-mediated Transport In Synapse Syntaxin-1 Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Organelle Localization Regulation Of Regulated Secretory Pathway SNARE Complex Assembly Positive Regulation Of Exocytosis Regulation Of Exocytosis Neurotransmitter Transport Membrane Organization Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Secretion By Cell Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Secretory Granule Regulation Of Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Presynaptic Dense Core Vesicle Exocytosis Regulation Of Transport Regulation Of Calcium Ion-dependent Exocytosis Phagocytic Vesicle Membrane Synaptic Vesicle Priming Secretory Granule Localization	SNAP Receptor Activity SNARE Complex SNARE Binding Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Membrane Organization Vesicle Organization Vesicle Docking Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Exocytosis Membrane Docking Positive Regulation Of Synaptic Transmission Syntaxin Binding Neuron Projection Long-term Synaptic Potentiation Azurophil Granule SNARE Complex Assembly Secretion By Cell Vesicle-mediated Transport Specific Granule Synaptic Vesicle Priming Organelle Localization Vesicle-mediated Transport In Synapse Secretion Regulation Of Protein Localization Neurotransmitter Transport Establishment Of Localization In Cell Protein Transport Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Calcium-ion Regulated Exocytosis Signal Release Establishment Of Protein Localization Regulation Of Protein Transport Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Chloride Channel Inhibitor Activity Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Intracellular Protein Transport Glutamatergic Synapse Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Cellular Component Assembly
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