STX3 and FXYD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STX3	FXYD3
Description		syntaxin 3	FXYD domain containing ion transport regulator 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Vacuole Plasma Membrane Cell-cell Junction Endomembrane System Membrane Apical Plasma Membrane Lamellipodium Secretory Granule Dendrite Growth Cone SNARE Complex Melanosome Specific Granule Azurophil Granule Zymogen Granule Membrane Neuron Projection Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Plasma Membrane Bounded Cell Projection	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Arachidonate Binding	Chloride Channel Activity Protein Binding Sodium Channel Regulator Activity ATPase Binding Ion Channel Regulator Activity
	Biological Process	Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Cell Adhesion Vesicle Docking Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Fusion Organelle Membrane Fusion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Regulation Of Monoatomic Ion Transport Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways		Other interleukin signaling	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183)
Interacting Genes		54 interacting genes: AQP6 CD79A COQ9 CPLX2 CPLX4 CREB3L1 CYB561 DNAJC5 EBAG9 ELOVL4 ERGIC3 EVI5 FAM209A FXYD3 GPR152 GPX8 JAGN1 LMNA MANBAL MGST3 MMGT1 MSMO1 MTIF3 NAPB PGRMC2 REEP4 RMDN3 SCN3B SLC10A6 SLC35H1 SLC71A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STX5 STXBP1 STXBP2 SYT1 SYT4 SYT7 TBC1D30 TMEM14B TMPPE TMX2 TRPC3 TXLNA UBC VAMP3 VAMP7 VAMP8 ZDHHC15	64 interacting genes: AGR3 ANK1 AQP6 AQP9 BCL2L13 BEST2 CD79A CNR2 CREB3 CREB3L1 CYB5R3 EBP ERG28 ERGIC3 FAM209A FBXL12 FCGR2A FFAR2 GHITM GPR152 GPR37L1 GPR42 GPRC5D IBSP KASH5 KCNN4 LMNA LTC4S MAPK6 MFSD11 MGST1 MTIF3 NR4A1 NUDT3 PLPP6 SCN3B SERBP1 SGPL1 SLC10A1 SLC10A6 SLC16A12 SLC18A1 SLC1A1 SLC30A2 SLC35A1 SLC35B1 SLC35H1 SLC39A2 SLC61A1 SPNS3 STRIT1 STX3 TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM179B TMEM50B TMEM52B TMEM80 TMEM86A TMEM97 TSPO2 XKR3
Entrez ID		6809	5349
HPRD ID		15985	05410
Ensembl ID		ENSG00000166900	ENSG00000089356
Uniprot IDs		A0A286YF28 Q13277 Q53YE2	A0A1S5UZ23 Q14802 S4R445
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis SNARE Complex Secretion By Cell SNARE Binding Vesicle Fusion Syntaxin Binding Organelle Membrane Fusion Organelle Localization By Membrane Tethering SNAP Receptor Activity Secretion Membrane Docking Organelle Fusion Regulated Exocytosis Synaptic Vesicle Exocytosis Membrane Fusion Vesicle Docking Vesicle Organization Membrane Signal Release Calcium-ion Regulated Exocytosis Vesicle-mediated Transport Positive Regulation Of Regulated Secretory Pathway Vesicle-mediated Transport In Synapse Syntaxin-1 Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Organelle Localization Regulation Of Regulated Secretory Pathway SNARE Complex Assembly Positive Regulation Of Exocytosis Regulation Of Exocytosis Neurotransmitter Transport Membrane Organization Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Secretion By Cell Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Secretory Granule Regulation Of Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Presynaptic Dense Core Vesicle Exocytosis Regulation Of Transport Regulation Of Calcium Ion-dependent Exocytosis Phagocytic Vesicle Membrane Synaptic Vesicle Priming Secretory Granule Localization	Membrane Transmembrane Transport Endoplasmic Reticulum Membrane Organic Anion Transport Endoplasmic Reticulum Protein Binding Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Sterol Biosynthetic Process Monoatomic Ion Transport UDP-glucose Transmembrane Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoatomic Cation Transport Plasma Membrane Zinc Ion Transmembrane Transport Zinc Ion Transport Bile Acid:sodium Symporter Activity Inorganic Ion Transmembrane Transport Organic Hydroxy Compound Transport Steroid Biosynthetic Process Cholesterol Biosynthetic Process Metal Ion Transport Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoatomic Anion Channel Activity Monoatomic Ion Transmembrane Transport Channel Activity Inorganic Cation Transmembrane Transport Nuclear Membrane Monoatomic Cation Transmembrane Transport Antiporter Activity Amine Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress
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