PDCD10 and STK25

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		PDCD10	STK25
Description		programmed cell death 10	serine/threonine kinase 25
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome FAR/SIN/STRIPAK Complex	Cytoplasm Golgi Apparatus Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein Homodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Angiogenesis Endothelium Development Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAP Kinase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Notch Signaling Pathway Regulation Of Angiogenesis Protein Stabilization Establishment Of Golgi Localization Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Reassembly Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Leukemia Inhibitory Factor	Protein Phosphorylation Response To Oxidative Stress Establishment Or Maintenance Of Cell Polarity Signal Transduction Axonogenesis Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Protein Autophosphorylation Positive Regulation Of Axonogenesis Golgi Localization Establishment Of Golgi Localization Golgi Reassembly
Pathways
Drugs
Diseases		Cerebral cavernous malformation
GWAS		Fast beta electroencephalogram ( 28070124) Platelet count ( 32888494)	Medication use (thyroid preparations) ( 31015401) Prostate cancer ( 23535732) Vitiligo ( 27723757)
Interacting Genes		9 interacting genes: CHMP5 FAM118B FARSA FRYL MINAR1 PLEKHS1 STK24 STK25 STRN	17 interacting genes: APP CCNDBP1 CEP70 GOLGA2 GOLGA6L9 IHO1 IKBKG LRRK2 MFHAS1 MTDH NEDD4 OGT PDCD10 TRIM27 UBE2D3 YWHAZ ZDHHC17
Entrez ID		11235	10494
HPRD ID		10141	03770
Ensembl ID		ENSG00000114209	ENSG00000115694
Uniprot IDs		Q9BUL8	A0A024R4B2 A0A0S2Z4Y2 B3KRS6 B4DMA5 B4DVS7 B4E185 O00506 Q96BA2
PDB IDs		3AJM 3L8I 3L8J 3RQE 3RQF 3RQG 3W8H 3W8I 4GEH 4TVQ	2XIK 3W8H 4NZW 7Z4V
Enriched GO Terms of Interacting Partners?		FAR/SIN/STRIPAK Complex Regulation Of Neuron Projection Development Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Mitotic Cytokinetic Process Cytokinetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation	Positive Regulation Of Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Protein Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Signal Transduction Response To Catecholamine Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Positive Regulation Of Proteolysis Positive Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Golgi Organization Golgi Reassembly Protein Modification Process Positive Regulation Of Catabolic Process Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization Cellular Response To Dopamine Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Response To Dopamine Positive Regulation Of Autophagy Establishment Of Golgi Localization Innate Immune Response Regulation Of Proteolysis Cellular Response To Manganese Ion Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Progesterone Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Defense Response To Symbiont Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Localization In Cell
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