PDCD10 and STK25

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		PDCD10	STK25
Gene Name		programmed cell death 10	serine/threonine kinase 25
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Protein Homodimerization Activity Protein N-terminus Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Angiogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Rho Protein Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAP Kinase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Notch Signaling Pathway Protein Stabilization Establishment Of Golgi Localization Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Reassembly Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis	Protein Phosphorylation Apoptotic Process Response To Oxidative Stress Establishment Or Maintenance Of Cell Polarity Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Response To Hydrogen Peroxide Regulation Of Cell Differentiation Protein Autophosphorylation Positive Regulation Of Axonogenesis Golgi Localization Establishment Of Golgi Localization Golgi Reassembly
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: C4orf19 CHMP5 STK24 STK25 STK26	13 interactors: APP CCDC36 CCNDBP1 CEP70 GOLGA2 IKBKG LRRK2 NEDD4 PDCD10 TRIM27 UBE2D3 YWHAZ ZDHHC17
Entrez ID		11235	10494
HPRD ID		10141	03770
Ensembl ID		ENSG00000114209	ENSG00000115694
Uniprot IDs		Q9BUL8	A8K6Z3 B3KRS6 B4DMA5 B4DVS7 B4E185 B7Z9K1 O00506 Q96BA2
PDB IDs		3AJM 3L8I 3L8J 3RQE 3RQF 3RQG 3W8H 3W8I 4GEH	2XIK 3W8H
Enriched GO Terms of Interacting Partners?		Response To Hydrogen Peroxide Response To Reactive Oxygen Species Protein Autophosphorylation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Golgi Reassembly Protein Phosphorylation Signal Transduction By Phosphorylation Establishment Of Golgi Localization Establishment Of Organelle Localization Golgi Inheritance Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Regulation Of Neuron Projection Development Golgi Localization Regulation Of Spindle Assembly Organelle Localization Phosphorylation Regulation Of Cellular Component Organization Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Mitotic Spindle Organization Regulation Of Cell Projection Organization Microvillus Assembly Microvillus Organization Regulation Of Neuron Differentiation Regulation Of Axon Regeneration Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Regulation Of Receptor Recycling Regulation Of Neurogenesis Regulation Of Response To Reactive Oxygen Species Endosome To Lysosome Transport Metaphase Plate Congression Phosphate-containing Compound Metabolic Process Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Cell Development Lysosomal Transport Regulation Of Centrosome Cycle Regulation Of Cellular Response To Oxidative Stress	Golgi Reassembly Neuromuscular Junction Development Establishment Of Golgi Localization Cell Death Golgi Inheritance Death Positive Regulation Of Signal Transduction Immune Response Regulation Of Protein Kinase Activity Golgi Localization Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Organelle Localization Regulation Of Protein Binding Cellular Localization Response To Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Apoptotic Process Protein Polyubiquitination Synapse Organization Programmed Cell Death Regulation Of Protein Phosphorylation Intracellular Receptor Signaling Pathway Protein K63-linked Ubiquitination Regulation Of Signal Transduction Signal Transduction Positive Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Monoubiquitination Establishment Of Localization In Cell Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Binding Regulation Of Signaling Regulation Of Phosphorylation Cell Communication Defense Response Immune System Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Protein Binding Regulation Of MAP Kinase Activity Vesicle-mediated Transport TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Death Establishment Of Organelle Localization MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		4b adriamycin ataxia carboplatin coded ct cyclophosphamide desirable eif4b isoaspartate matr3 matrin meiotic microrchidia morc3 pbl pbls pcmtd2 personalised psmb1 rmnd5a runt runx2 sacm1l subtraction telangiectasia tmem66 undesired znf644	candidates drosophila hepg2 highlight hippo mammals map4k3 mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk39 stradalpha talk tao2 taz tead1 yap1
Tagcloud (Difference) ?		4b adriamycin ataxia carboplatin coded ct cyclophosphamide desirable eif4b isoaspartate matr3 matrin meiotic microrchidia morc3 pbl pbls pcmtd2 personalised psmb1 rmnd5a runt runx2 sacm1l subtraction telangiectasia tmem66 undesired znf644	candidates drosophila hepg2 highlight hippo mammals map4k3 mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk39 stradalpha talk tao2 taz tead1 yap1
Tagcloud (Intersection) ?