PDCD10 and FRYL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDCD10	FRYL
Description		programmed cell death 10	FRY like transcription coactivator
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome FAR/SIN/STRIPAK Complex	Cell Cortex Site Of Polarized Growth
	Molecular Function	Protein Binding Protein Kinase Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Angiogenesis Endothelium Development Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of MAP Kinase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Notch Signaling Pathway Regulation Of Angiogenesis Protein Stabilization Establishment Of Golgi Localization Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Golgi Reassembly Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Leukemia Inhibitory Factor	Cell Morphogenesis Neuron Projection Development
Pathways
Drugs
Diseases		Cerebral cavernous malformation
GWAS		Fast beta electroencephalogram ( 28070124) Platelet count ( 32888494)	Bipolar disorder ( 31043756) Height ( 31562340) Hemoglobin ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 29403010) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: CHMP5 FAM118B FARSA FRYL MINAR1 PLEKHS1 STK24 STK25 STRN	6 interacting genes: CCDC187 DISC1 PDCD10 PELI2 PRR35 SHANK3
Entrez ID		11235	285527
HPRD ID		10141	18995
Ensembl ID		ENSG00000114209	ENSG00000075539
Uniprot IDs		Q9BUL8	A0A2C9F2R7 B3KXG5 O94915 Q6ZR29
PDB IDs		3AJM 3L8I 3L8J 3RQE 3RQF 3RQG 3W8H 3W8I 4GEH 4TVQ
Enriched GO Terms of Interacting Partners?		FAR/SIN/STRIPAK Complex Regulation Of Neuron Projection Development Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Mitotic Cytokinetic Process Cytokinetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation	Structural Constituent Of Presynaptic Actin Cytoskeleton Actin Filament Bundle Assembly Actin Filament Bundle Organization Cytoskeleton Organization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Dendritic Spine Development Organelle Organization Actin Filament Bundle Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Establishment Of Golgi Localization Golgi Reassembly Positive Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Protein Phosphorylation Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Neurogenesis Regulation Of Postsynapse Organization Pyramidal Neuron Migration To Cerebral Cortex Cerebral Cortex Radial Glia-guided Migration Central Region Of Growth Cone Regulation Of Toll Signaling Pathway Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Observational Learning Striatal Medium Spiny Neuron Differentiation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphorylation Postsynaptic Density Postsynaptic Specialization Assembly Actin Filament Organization GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Nervous System Development Endothelium Development Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
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