ELOVL4 and MALL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ELOVL4	MALL
Description		ELOVL fatty acid elongase 4	mal, T cell differentiation protein like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Golgi Membrane Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft
	Molecular Function	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity Transferase Activity	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process	Myelination Cholesterol Homeostasis
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs		Omega-3-carboxylic acids
Diseases		Stargardt disease (STGD); Fundus flavimaculatus
GWAS		Aging ( 22773346) Body mass index ( 23669352) Chronic obstructive pulmonary disease ( 28166215) Daytime sleep phenotypes ( 27126917) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Partial epilepsies ( 20522523) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		106 interacting genes: ADGRE2 ANKRD46 APOL2 APOL3 ARLN ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CDIPT CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 EMC6 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 INSIG2 ITGAM JAGN1 LEPROTL1 LHFPL5 LPAR3 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PEX16 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SMCO4 SMIM1 SNORC STX3 STX8 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB VMA12 YIF1A YIPF6 ZDHHC21 ZFPL1	69 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 ERGIC3 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35H1 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3
Entrez ID		6785	7851
HPRD ID		05697	15997
Ensembl ID		ENSG00000118402	ENSG00000144063
Uniprot IDs		Q9GZR5	Q13021
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Fusion Organelle Fusion Organelle Membrane Fusion Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Protein Localization Vesicle Fusion Protein Binding Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Cellular Localization Sterol Biosynthetic Process Establishment Of Protein Localization To Membrane Golgi Membrane Steroid Biosynthetic Process Mitochondrial Membrane Membrane Docking Structural Constituent Of Myelin Sheath Intracellular Transport Endoplasmic Reticulum Organization Heme Oxidation Heme Oxygenase (decyclizing) Activity Transport Vesicle SNARE Complex Assembly Lipid Biosynthetic Process Organelle Localization By Membrane Tethering Sterol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Apparatus Insulin Metabolic Process Inorganic Ion Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Establishment Of Localization In Cell Intracellular Protein Localization Intracellular Chemical Homeostasis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Vesicle Docking Steroid Metabolic Process	Membrane Protein Binding Plasma Membrane Caveolar Macromolecular Signaling Complex Nuclear Envelope Adaptive Immune Response Natural Killer Cell Inhibitory Signaling Pathway Endoplasmic Reticulum-autophagosome Adaptor Activity Carbohydrate Binding External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Membrane Organization Immune Response-regulating Signaling Pathway Lipid Storage Positive Regulation Of Hypersensitivity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Substrate Localization To Autophagosome Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Fatty Acid Elongation, Saturated Fatty Acid Mitochondrial Outer Membrane Permeabilization Caveola Assembly Organic Hydroxy Compound Transport Regulation Of Response To Endoplasmic Reticulum Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Mitochondrial Protein Catabolic Process Plasma Membrane Raft Assembly Negative Regulation Of T Cell Mediated Cytotoxicity Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Acute Inflammatory Response Immune Response-inhibiting Signal Transduction
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