ELOVL4 and STX8

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		ELOVL4	STX8
Description		ELOVL fatty acid elongase 4	syntaxin 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Plasma Membrane Endomembrane System Membrane SNARE Complex Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity Transferase Activity	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process	Intracellular Protein Transport Vesicle Fusion Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Type II Interferon Regulation Of Protein Localization To Plasma Membrane
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs		Omega-3-carboxylic acids
Diseases		Stargardt disease (STGD); Fundus flavimaculatus
GWAS		Aging ( 22773346) Body mass index ( 23669352) Chronic obstructive pulmonary disease ( 28166215) Daytime sleep phenotypes ( 27126917) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Partial epilepsies ( 20522523) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		106 interacting genes: ADGRE2 ANKRD46 APOL2 APOL3 ARLN ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CDIPT CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 EMC6 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 INSIG2 ITGAM JAGN1 LEPROTL1 LHFPL5 LPAR3 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PEX16 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SMCO4 SMIM1 SNORC STX3 STX8 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB VMA12 YIF1A YIPF6 ZDHHC21 ZFPL1	84 interacting genes: ACVR1 AMIGO1 AQP2 AQP6 ARL13B ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SLC35H1 SSMEM1 STAR STMN4 STX1A STX2 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VPS11 VPS18 VTI1B WDR91
Entrez ID		6785	9482
HPRD ID		05697	05012
Ensembl ID		ENSG00000118402	ENSG00000170310
Uniprot IDs		Q9GZR5	Q9UNK0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Fusion Organelle Fusion Organelle Membrane Fusion Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Protein Localization Vesicle Fusion Protein Binding Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Cellular Localization Sterol Biosynthetic Process Establishment Of Protein Localization To Membrane Golgi Membrane Steroid Biosynthetic Process Mitochondrial Membrane Membrane Docking Structural Constituent Of Myelin Sheath Intracellular Transport Endoplasmic Reticulum Organization Heme Oxidation Heme Oxygenase (decyclizing) Activity Transport Vesicle SNARE Complex Assembly Lipid Biosynthetic Process Organelle Localization By Membrane Tethering Sterol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Apparatus Insulin Metabolic Process Inorganic Ion Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Establishment Of Localization In Cell Intracellular Protein Localization Intracellular Chemical Homeostasis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Vesicle Docking Steroid Metabolic Process	Membrane Syntaxin Binding Endoplasmic Reticulum Membrane SNARE Binding Membrane Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Docking Protein Binding Vesicle Docking Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Protein Transport Organelle Fusion Chloride Channel Inhibitor Activity Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Endomembrane System SNARE Complex Disassembly Soluble NSF Attachment Protein Activity Membrane Organization Transmembrane Transport Cellular Localization Endoplasmic Reticulum Neurotransmitter Transport Neurotransmitter Reuptake Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutathione Peroxidase Activity Establishment Of Protein Localization Intracellular Transport Transforming Growth Factor Beta Receptor Activity, Type I Leukotriene-C4 Synthase Activity Protein Transport Presynaptic Active Zone Membrane Norepinephrine Uptake Neurotransmitter Uptake Plasma Membrane Golgi Vesicle Transport Activin Receptor Complex Activin Receptor Activity, Type I CORVET Complex Lysosomal Membrane Renal Water Transport Voltage-gated Potassium Channel Complex Serotonin Uptake Norepinephrine Transport Protein-containing Complex Disassembly
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