NEIL3 and BTN1A1

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		NEIL3	BTN1A1
Description		nei like DNA glycosylase 3	butyrophilin subfamily 1 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding	Signaling Receptor Binding Protein Binding Signaling Receptor Activity
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination	Regulation Of Cytokine Production T Cell Receptor Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs	Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)	Age at first sexual intercourse ( 27089180) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Educational attainment (years of education) ( 23722424) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 31527586 34187846) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Iron status biomarkers ( 19084217) Liver iron content ( 34128465) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Weight ( 28552196)
Interacting Genes		54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B	4 interacting genes: MEOX2 MOSPD2 NEIL3 XDH
Entrez ID		55247	696
HPRD ID		16407	03365
Ensembl ID		ENSG00000109674	ENSG00000124557
Uniprot IDs		Q8TAT5	Q13410 Q4VAN2
PDB IDs		7JL5 7TMY
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Xanthine Catabolic Process Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Hypoxanthine Oxidase Activity Hypoxanthine Catabolic Process Hypoxanthine Dehydrogenase Activity MCM Complex Binding Guanine Catabolic Process Deoxyguanosine Catabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Somite Specification Molybdopterin Cofactor Binding Hypoxanthine Metabolic Process Purine Ribonucleoside Catabolic Process DAMP Catabolic Process GMP Catabolic Process AMP Catabolic Process Purine Deoxyribonucleoside Metabolic Process Deoxyadenosine Catabolic Process Adenosine Catabolic Process Purine Nucleobase Catabolic Process IMP Catabolic Process Depurination Endoplasmic Reticulum-endosome Membrane Contact Site FFAT Motif Binding Guanine Metabolic Process Deoxyribonucleoside Catabolic Process DGMP Catabolic Process DGMP Metabolic Process Purine Nucleoside Catabolic Process Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Allantoin Metabolic Process Bubble DNA Binding Adenosine Metabolic Process DNA N-glycosylase Activity Purine Nucleoside Monophosphate Catabolic Process Single Strand Break Repair DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Organelle Membrane Contact Site Amide Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Deoxyribonucleoside Monophosphate Catabolic Process Segment Specification Somite Development Base-excision Repair, AP Site Formation Lipid Droplet Formation IMP Metabolic Process Purine Nucleobase Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?