NEIL3 and FAM120A

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		NEIL3	FAM120A
Description		nei like DNA glycosylase 3	family with sequence similarity 120 member A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding	RNA Binding Protein Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
Drugs
Diseases
GWAS		Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)	Ability to confide in someone ( 29970889) Anxiety ( 33859377) Body mass index ( 25953783) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Coffee consumption ( 31046077) Depression ( 33859377) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Multisite chronic pain ( 33830993) Upper eyelid morphology ( 29921221)
Interacting Genes		54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B	10 interacting genes: ATP5F1C CEBPA DYSF LCOR NEIL3 PRKN RBPMS RNF10 SNCA UBXN7
Entrez ID		55247	23196
HPRD ID		16407	12928
Ensembl ID		ENSG00000109674	ENSG00000048828
Uniprot IDs		Q8TAT5	A0A8V8TNY3 Q9NZB2
PDB IDs		7JL5 7TMY
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Dopamine Uptake Involved In Synaptic Transmission Regulation Of Neurotransmitter Secretion Catecholamine Uptake Dopamine Uptake Histone Deacetylase Binding Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Phospholipase Binding Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Synaptic Transmission, Dopaminergic Ubiquitin-specific Protease Binding Regulation Of Dopamine Secretion Cellular Response To Metal Ion Monoamine Transport Amyloid Fibril Formation Neurotransmitter Uptake Regulation Of Synaptic Vesicle Recycling Dopamine Metabolic Process Negative Regulation Of Exocytosis Terminal Bouton Regulation Of Catecholamine Secretion Regulation Of Reactive Oxygen Species Biosynthetic Process Catecholamine Metabolic Process Hsp70 Protein Binding Mitochondrion Organization Transcription Cis-regulatory Region Binding Response To Xenobiotic Stimulus RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Protein Monoubiquitination Negative Regulation Of Spontaneous Neurotransmitter Secretion Protein Destabilization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Monocyte Activation Involved In Immune Response MCM Complex Binding Macrophage Activation Regulation Of Endocytosis Generation Of Precursor Metabolites And Energy Biogenic Amine Metabolic Process Protein Autoubiquitination Response To Lipid Response To Metal Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process
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