NEIL3 and CCN1

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		NEIL3	CCN1
Description		nei like DNA glycosylase 3	cellular communication network factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Growth Factor Binding Extracellular Matrix Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination	Osteoblast Differentiation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Apoptotic Process Chemotaxis Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Atrial Septum Morphogenesis Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Regulation Of Multicellular Organismal Development Positive Regulation Of Ceramide Biosynthetic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823)
Interacting Genes		54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B	8 interacting genes: ANXA1 CDC42 DYRK1A ITGAV ITGB5 NEIL3 SMPD2 UBQLN2
Entrez ID		55247	3491
HPRD ID		16407	09089
Ensembl ID		ENSG00000109674	ENSG00000142871
Uniprot IDs		Q8TAT5	O00622 Q6FI18
PDB IDs		7JL5 7TMY	4D0Z 4D11
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Integrin Alphav-beta5 Complex Regulation Of Vesicle-mediated Transport Phagocytic Vesicle Regulation Of Endocytosis Integrin-mediated Signaling Pathway Mononuclear Cell Migration Wound Healing, Spreading Of Epidermal Cells Focal Adhesion Cell Migration Endocytosis Apoptotic Cell Clearance Cell Motility Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Import Into Cell Leukocyte Migration Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Chemotaxis Regulation Of Interleukin-2 Production Histone H3T45 Kinase Activity Entry Into Host Cell By A Symbiont-containing Vacuole Formation Of Primary Germ Layer Opsonin Binding MCM Complex Binding Regulation Of Transport Locomotion Actin Cytoskeleton Organization Signaling Receptor Binding Actin Filament-based Process Phagocytosis Actin Filament GBD Domain Binding Storage Vacuole Integrin Alphav-beta3 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Virus Receptor Activity Integrin Alphav-beta8 Complex Negative Regulation Of G Protein-coupled Receptor Internalization Cell Periphery Negative Regulation Of Transport Regulation Of Phagocytosis Cell-matrix Adhesion Endothelin Receptor Signaling Pathway Involved In Heart Process Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex
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