STATH and SGPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STATH	SGPL1
Description		statherin	sphingosine-1-phosphate lyase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Extracellular Matrix Constituent, Lubricant Activity Structural Constituent Of Tooth Enamel Hydroxyapatite Binding	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Ossification Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Biomineral Tissue Development Defense Response To Bacterium Saliva Secretion	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways			Sphingolipid catabolism
Drugs			Pyridoxal phosphate
Diseases
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		30 interacting genes: AQP6 C16orf92 DERL3 ERGIC3 FAM209A FAM210B FCRL3 FKBP7 GET3 GPR152 GPR42 KCNJ6 LEUTX MRM1 MTIF3 OPRPN OVGP1 REEP4 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SLC39A2 SLC61A1 SPNS3 TFAM TLCD4 TMEM80 TMX2	34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50
Entrez ID		6779	8879
HPRD ID		01696	07224
Ensembl ID		ENSG00000126549	ENSG00000166224
Uniprot IDs		P02808	A0A8V8TN35 O95470
PDB IDs			4Q6R 8AYF
Enriched GO Terms of Interacting Partners?		Bile Acid:sodium Symporter Activity	Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport
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